Research Groups

Virander Chauhan

Mammalian Biology: Malaria

Visiting Scientist

Virander S. Chauhan

International Centre for Genetic Engineering and Biotechnology
Aruna Asaf Ali Marg
110 067 New Delhi, India

E-mail: virandericgeb.res.in
Office tel: +91-11-26742317, 26741358/61, 26742357/60 (EPBX)
Office fax: +91-11-26742316

Education

Delhi University, New Delhi, India, MSc (Chemistry), 1971
Delhi University, New Delhi, India, PhD (Chemistry), 1974
Oxford University, UK, PhD, 1977

Career History

1998-2014, Director of the New Delhi Component of the International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi, India.
Since 1988, Senior Scientist and Group Leader of the Malaria Research Group of the ICGEB in New Delhi.
1986-1988, Professor, Department of Chemistry, Delhi University, New Delhi.
1982-1986, Reader, Department of Chemistry, Delhi University, New Delhi.
1979-1981, Assistant Professor, Indian Institute of Technology (IIT), Kanur, India.
1977-1978, Postdoctoral Fellow, Department of Chemistry, University of Georgia, Atlanta, USA.
1971-1979, Lecturer, St. Stephen's College, Delhi University, New Delhi.

Scientific Activity

Research interests are in malaria vaccine and drug development research. His Group has developed procedures to prepare recombinant vaccine target antigens and with industrial partners, vaccine formulation has been developed for clinical trial, in India. His work on understanding the mechanism of actions of antimalarial drugs like chloroquine and artemisinin has led to the development of high throughput screens for malaria drug discovery. Another research interest of his Group is in the area of design, synthesis and utility of conformationally defined peptides. This work has proven useful in the design of antibiotic peptide, anti amyloid and more recently, in self assembling systems.

Selected publications

VS Chauhan on PubMed

Hans, N., Singh, S., Jain, S.K., Chauhan, V.S. 2013. Identification of Novel Rhoptry Neck Protein of Plasmodium falciparu. Mol Biochem Parasitol 10743 188, 34-39

Maurya, I.K., Thota, C.K., Verma, S.D., Sharma, J., Rawal, M.K., Ravikumar, B., Sen, S., Chauhan, N., Lynn, A.M., Chauhan, V.S., Prasad, R. 2013. Rationally designed transmembrane peptide mimics of the multidrug transporter protein Cdr1 act as antagonists to selectively block drug efflux and chemosensitize azole-resistant clinical isolates of Candida albicans. J Biol Chem 288, 16775-16787

Mishra A., Vaishnavi T.S., Thota C.K., Gupta M., Ramakumar S., Chauhan V.S. 2013. Conformationally restricted short peptide inhibit human islet amyloid polypeptide (hIIAPP) fibrillization. Chem Comm 49, 2688-2690

Panda J.J., Kaul A., Kumar S., Alam S., Mishra A.K., Kundu G.C., Chauhan V.S. 2013. Modified dipeptide-based nanoparticles: vehicles for targeted tumor drug delivery. Nanomedicine (Lond)

Alam A, Bhatnagar R. K., Chauhan V.S. 2012. Expression and characterization of catalytic domain of Plasmodiu falciparum subtilisin-like protease 3. Mol Biochem Parasitol 183, 84–89

Mwanaidi Y. Kafuye-Mlwilo, Mukherjee P., Chauhan V.S. 2011. Kinetic of humoral and memory B cell response induced by Plasmodium falciparum Merozoite Surface Protein-119 in mice. Infect Immun 80(2), 633

Saini A., Chauhan V.S. 2011. Delineation of the Core Aggregation Sequences of TDP-43 C-Terminal Fragment. Chembiochem 12, 2495-2501

Pathak S., Chauhan V.S. 2011. Rationale-based, de novo design of dehydrophenylalanine-containing antibiotic peptides and systematic modification in sequence for enhanced potency. Antimicrob Agents and Chemother 55, 2178-2188 

Mazumdar S., Mukherjee P., Yazdani S.S., Jain S.K., Mohmmed A., Chauhan V.S.  2010. Plasmodium falciparum merozoite surface protein 1 (MSP-1)-MSP-3 chimeric protein: immunogenicity determined with human-compatible adjuvants and induction of protective immune response. Infect Immun 78, 872-883

Mukherjee P., Chauhan V.S. 2008. Plasmodium falciparum-free merozoites and infected RBCs distinctly affect soluble CD40 ligand-mediated maturation of immature monocyte-derived dendritic cells. J Leuk Biol 84, 244-254

Gupta M., Bagaria A., Mishra A., Mathur P., Basu A., Ramakumar S., Chauhan V.S. 2007. Self-assembly of a dipeptide-containing conformationally restricted dehydrophenylalanine. Adv Mat  19, 858-861

Gupta A., Mehrotra R., Klimov E., Siesler H.W., Joshi R.M., Chauhan V.S. 2006. Thermal stability of dehydrophenylalanine-containing model peptides as probed by infrared spectroscopy: a case study of α-Helical and a 310-Helical peptide. Chem & Biod 3, 284-295

Chauhan V.S., Ramagopal U.A., Ramakumar S. Sahal D. 2001. De novo design and characterization of an apolar helical hairpin peptide at atomic resolution: compaction mediated by weak interactions. Proc Natl Acad Sci USA 98, 870-874

Pandey A.V., Tekwani B.L., Singh, R.L., Chauhan V.S. 1999. Artemisinin, an endoperoxide antimalarial, disrupts the hemoglobin catabolism and heme detoxification systems in malarial parasite. J Biol Chem 274, 19383-19388

Chauhan V.S., Jain R.M., Rajashankar K.R., Ramakumar S. 1997. First observation of left-handed helical conformation in a dehydro peptide containing two L-Val residues. crystal and solution structure of Boc-L-Val-ΔPhe-ΔPhe-ΔPhe-L-Val-OMe. J Am Chem Soc. 119, 3205-3211

ICGEB New Delhi

ICGEB Campus
Aruna Asaf Ali Marg
110 067 New Delhi
INDIA
Tel: +91-11-26741358
Fax: +91-11-26742316
icgebicgeb.res.in

 

 

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