Research Groups

Tanushri Kaul

Nutritional Improvement of Crops

Group Leader

Research Interests and Description

Tanushri Kaul

International Centre for Genetic Engineering and Biotechnology
Aruna Asaf Ali Marg
110 067 New Delhi, India

E-mail: tanushriicgeb.res.in
Tel: +91-11-26742962, +91-11-26741007 Ext 373
Fax: +91-11-26742316

Education

Delhi University, Department of Botany, New Delhi, India, PhD, 2002
IGNOU, School of Management Studies, New Delhi, India, DIM, 2000
Delhi University, Department of Botany, New Delhi, India, M. Phil, 1996
Delhi University, Central Institute of Education, New Delhi, India, BEd, 1995
Delhi University, Department of Botany, New Delhi, India, MSc, 1994

Career History

Group Leader, Nutritional Improvement of Crops since 2016.
2012, Research Scientist in Plant Molecular Biology Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi, India
2012, Biocare Award and Fellowship, Plant Molecular Biology Group, ICGEB
2011, Rapid Grant for Young Investigator Award, Plant Molecular Biology Group, ICGEB
2010-2011, Research Associateship, Plant Molecular Biology Group, ICGEB-IPK Gatersleben
2008-2010, Research Scientist, Centre for Excellence Project, Plant Molecular Biology Group, ICGEB
2006-2008, Post Doctoral-Indo-Israel DST Fellowship ICGEB-ARO-Volcani Centre, Bet Dagan, Israel
2004-2006, DBT-IISC-Post Doctoral FellowshipICGEB
2003-2004, Research Scientist, Indo-Belarus DST Project, Plant Molecular Biology Group, ICGEB

Scientific Activity

Designing phytase-rich tomatoes (expressing Bacillus and Aspergillus phytases) and phytate-free cereals (wheat, rice, maize) and legumes for alleviating global micronutrient malnutrition. Single best strategy is to remove PA in cereal and legume seeds consumed globally by gene deletor technology. Developing wheat grains expressing a NAC transcription factor to re-mobilize Fe3+, Zn2+and proteins.

Efficiently scavenge ROS during late maturation and postharvest stages of tomato fruits by overexpression of the ascorbate-glutathione pathway genes to enhance their shelf life as well as their antioxidant value and reduce the postharvest losses. This biotechnological approach may be extrapolated to other fruits and vegetables.

Efficient genome modification of the target site of EPSPS and ALS genes in maize, rice and wheat by CRISPR-Cas9/Nickase/Cpf1 to confer resistance to herbicides and develop cisgenic cereal plants tolerant to non-selective herbicides. Technology shall be extrapolated to other crops that face weed constraint. Crispr/Cas9 genome editing to decipher loss or gain of function of novel genes coding for proteins with hypothetical functions that are involved in crop improvement-nutritive, stress and yield.

Deciphering the underlying regulatory mechanism of DNA replication and homologous recombination, a crucial DNA repair process essential for genome stability and accurate chromosome condensation or segregation during meiosis.

Enhancing the photosynthetic capacity an yield of rice by installation of a minimal C4 pathway from Pennisetum glaucum. 

Selected publications

Kaul, T., Reddy, C.S., Pandey, S. 2017. Transgenics with Monellin. In: Sweeteners Reference Series in Phytochemistry. Springer Publications DOI 10.1007/978-3-319-26478-3_20-1

Reddy, C.S., Kim, S.-C., Kaul, T. 2017 Genetically modified phytase crops rolein sustainable plant and animal nutrition and ecological development: a review. 3 Biotech 7, 195. DOI: 10.1007/s13205-017-0797-3

Pandey, S., Fartyal, D., Raina, V., Negi, Y.K., Reddy, M.K., Kaul, T. 2017. Abiotic Stress Tolerance in Plants: Myriad Roles of Ascorbate Peroxidase. Frontiers in Pl Sci 8, 581; Doi: 10.3389/fpls.2017.0058

John, R., Raja, V., Ahmad, M., Jan, N., Kaul, T. 2017. Trehalose: Metabolism and Role in Stress Signaling in Plants, In: Stress Signaling in Plants: Genomics and Proteomics Perspective, Vol 2, pp.261-275,  Sarwat Met al., Springer Publications. DOI 10.1007/978-3-319-42183-4_11

Yadava, P., Alok, A., Singh, R., Singh, I., Kaul, T., Pattanayak, A., Agrawal, P.K. 2017. Advances in Maize Transformation Technologies and Development of Transgenic Maize. Front Plant Sci 7, 1949

Malik, M,, Pandey, S., Tripathi, K., Jain, R. Kaul, T. 2017. Structural Model of TaNAM-B1 Transcription Factor from Wheat (Triticum aestivum) Insight into the Nutritional Grain Quality. Jour Proteomics & Bioinformatics 10, 8 DOI: 10.4172/jpb.1000441

John R, Uma Ganeshan, BN Singh, Tanushri Kaul, Reddy MK, Sopory SK, Rajam MV (2016) Overexpression of topoisomerase II improves salinity stress in tobacco. Frontiers in Pl Sci 7: 1280. DOI:10.3389/fpls.2016.01280

Singh, B.N., Mudgil, Y., Jhon, R., Achary, V.M.M., Tripathy, M.K., Sopory, S., Reddy, M.K., Kaul, T* (2015) Cell cycle stage-specific differential expression of Topoisomerase I in tobacco BY-2 cells and its ectopic overexpression and knockdown unravels its crucial role in plant morphogenesis and development. Plant Sci. 240:182-192.

Reddy, C.S., Vijaylakshmi, M, Reddy, M.K., Kaul, T*. (2015) Improving flavour and quality of tomatoes by expression of synthetic gene encoding sweet protein monellin. Mol. Biotechnology 2015 May;57(5):448-53. DOI: 10.1007/s12033-015-9838-5.

Reddy, C. S., Achary, V. M. M., Manna, M., Singh, J., Reddy M.K, Kaul, T*, (2015) Isolation and Molecular Characterization of Thermostable Phytase from Bacillus subtilis. Appl Biochem Biotechnology. DOI: 10.1007/s12010-015-1487-4.

Islam, T. Manna, M., Kaul, T*, Pandey, S., Reddy, C.S., Reddy, M.K. (2015) Genome wide dissection of Arabidopsis and Rice for the identification and expression analysis of glutathione peroxidases reveals their stress-specifc and overlapping response patterns. Plant Mol Biol Rep 33:1413–1427

Singh, J., Pandey, P., James, D., Chandrasekhar, K., Achary, V. M. M., Kaul, T., Tripathy, B.C., Reddy, M. K. (2014) Enhancing C3 photosynthesis: An outlook on feasible interventions for crop improvement. Plant Biotchnol J 12(9):1217-1230. DOI: 10.1111/pbi.12246

 

 

 

ICGEB New Delhi

ICGEB Campus
Aruna Asaf Ali Marg
110 067 New Delhi
INDIA
Tel: +91-11-26741358/1007
Fax: +91-11-26742316
icgebicgeb.res.in

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