Research Groups

Tanushri Kaul

Nutritional Improvement of Crops

Group Leader

Research Interests and Description

Tanushri Kaul

International Centre for Genetic Engineering and Biotechnology
Aruna Asaf Ali Marg
110 067 New Delhi, India

E-mail: tanushriicgeb.res.in
Tel: +91-11-26742962, +91-11-26741007 Ext 373
Fax: +91-11-26742316

Education

Delhi University, Department of Botany, New Delhi, India, PhD, 2002
IGNOU, School of Management Studies, New Delhi, India, DIM, 2000
Delhi University, Department of Botany, New Delhi, India, M. Phil, 1996
Delhi University, Central Institute of Education, New Delhi, India, BEd, 1995
Delhi University, Department of Botany, New Delhi, India, MSc, 1994

Career History

Group Leader, Nutritional Improvement of Crops since 2016.
2012, Research Scientist in Plant Molecular Biology Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi, India
2012, Biocare Award and Fellowship, Plant Molecular Biology Group, ICGEB
2011, Rapid Grant for Young Investigator Award, Plant Molecular Biology Group, ICGEB
2010-2011, Research Associateship, Plant Molecular Biology Group, ICGEB-IPK Gatersleben
2008-2010, Research Scientist, Centre for Excellence Project, Plant Molecular Biology Group, ICGEB
2006-2008, Post Doctoral-Indo-Israel DST Fellowship ICGEB-ARO-Volcani Centre, Bet Dagan, Israel
2004-2006, DBT-IISC-Post Doctoral FellowshipICGEB
2003-2004, Research Scientist, Indo-Belarus DST Project, Plant Molecular Biology Group, ICGEB

Scientific Activity

Designing phytase-rich tomatoes (expressing Bacillus and Aspergillus phytases) and phytate-free cereals (wheat, rice, maize) and legumes for alleviating global micronutrient malnutrition. Single best strategy is to remove PA in cereal and legume seeds consumed globally by gene deletor technology. Developing wheat grains expressing a NAC transcription factor to re-mobilize Fe3+, Zn2+and proteins.

Efficiently scavenge ROS during late maturation and postharvest stages of tomato fruits by overexpression of the ascorbate-glutathione pathway genes to enhance their shelf life as well as their antioxidant value and reduce the postharvest losses. This biotechnological approach may be extrapolated to other fruits and vegetables.

Efficient genome modification of the target site of EPSPS and ALS genes in maize, rice and wheat by CRISPR-Cas9/Nickase/Cpf1 to confer resistance to herbicides and develop cisgenic cereal plants tolerant to non-selective herbicides. Technology shall be extrapolated to other crops that face weed constraint. Crispr/Cas9 genome editing to decipher loss or gain of function of novel genes coding for proteins with hypothetical functions that are involved in crop improvement-nutritive, stress and yield.

Deciphering the underlying regulatory mechanism of DNA replication and homologous recombination, a crucial DNA repair process essential for genome stability and accurate chromosome condensation or segregation during meiosis.

Enhancing the photosynthetic capacity an yield of rice by installation of a minimal C4 pathway from Pennisetum glaucum. 

Selected publications

Singh, BN, Mudgil, Y, Jhon, R, Tripathy, MK, Sopory, S, Reddy, MK, Kaul, T. 2015. Cell cycle stage-specific differential expression of Topoisomerase I in tobacco BY-2 cells and its ectopic overexpression and knockdown unravels its crucial role in plant morphogenesis and development. Plant Sci 240:182-92.

Manna, M., Islam T., Kaul T. , Reddy C.S., Fartyal D., James D., Reddy M.K. 2015. A comparative study of effects of increasing concentrations of phosphate and phosphite on rice seedlings. Acta Physiol Plant 37:258

Pandey, S, Reddy, CS, Yaqoob, U, Negi, Y.K., Arora, S, Kaul T 2015. Insilico analysis of cis acting regulatory elements CAREs in upstream regions of ascorbate glutathione pathway genes from Oryza sativa. Biochem. & Physiol. 4 (159), 2.

Mallick, M.A., Yaqoob, U, Mehta, J., Kaul, T. 2015. High frequency and rapid in vitro plant regeneration of Coleus forskohlii Briq. Medicinal & Aromatic Plants 4:193.

Pandey S, Priya S, Yakoob, U., Kumari T., Mallick M.A., Yadav A., Kaul T* 2015 A brief review: Introduction and mechanisms of Glutathione reductase –Role in Plant Stress Tolerance. J Environ Appl Biores 3 (03), 113–119.

Reddy, C.S., Vijaylakshmi, M, Reddy, M.K., Kaul, T. 2015 Improving flavour and quality of tomatoes by expression of synthetic gene encoding sweet protein monellin. Molecular Biotechnology 10.1007/s12033-015-9838-5.

Reddy, C. S., Achary, V. M. M., Manna, M., Singh, J., Kaul, T., Reddy M.K. 2015 Isolation and Molecular Characterization of Thermostable Phytase from Bacillus subtilis. Appl Biochem Biotechnology DOI: 10.1007/s12010-015-1487-4.

Islam, T. Manna, M., Kaul, T*, Pandey, S., Reddy, C.S., Reddy, M.K. (2015) Genome wide dissection of Arabidopsis and Rice for the identification and expression analysis of glutathione peroxidases reveals their stress-specifc and overlapping response patterns.Plant Mol Biol Reporter October 2015, Volume 33(5) pp 1413-142724.

Chandrasekhar, K., Reddy, G. M., Jitender, S., Vani, K., Vijayalakshmi, M., Kaul, T., Reddy, M. K. 2014. Development of transgenic rice harbouring mutated rice 5-enolpyruvylshikimate3-phosphate synthase (Os-mEPSPS) and Allium sativum leaf agglutinin (ASAL) genes conferring tolerance to herbicides and sap sucking insects. Plant Mol Biol Rep 32,1146-1157.

Singh, J., Pandey, P., James, D., Chandrasekhar, K., Achary, V. M. M., Kaul, T., Tripathy, B.C., Reddy, M. K. 2014. Enhancing C3 photosynthesis: An outlook on feasible interventions for crop improvement. Plant Biotechnol J, 1–14 doi: 10.1111/pbi.12246

Achary, V. M. M., Reddy, C. S., Pandey, P., Islam, T., Kaul, T., Reddy M. K. 2014 Glutathione reductase a unique enzyme: molecular cloning, expression and biochemical characterization from the stress-adapted C4 plant, Pennisetum glaucum (L.) R. Br. Mol Biol Rep 10.1007/s11033-014-3832-z

Chandrasekhar, K., Vijayalakshmi, M., Vani, K., Kaul, T., Reddy, M. K. 2014. Phloem-specific expression of the lectin gene from Allium sativum confers resistance to the sap-sucker Nilaparvata lugens. Biotechnol Lett 36, 1059-1067

Agarwal S, Sharma V, Kaul T, Abidin, MZ, Singh S. 2014. Cytotoxic Effect of Carotenoid Phytonutrient Lycopene on P. falciparum Infected Erythrocytes. Molecular Biochemical Parasitology 197(1-2):15-20

Islam, T. Manna, M., Kaul, T*, Pandey, S., Reddy, C.S., Reddy, M.K. (2014) Genome wide dissection of Arabidopsis and Rice for the identification and expression analysis of glutathione peroxidases reveals their stress-specifc and overlapping response patterns. Plant Mol Biol Rep DOI 10.1007/s11105-014-0846-6.

Sathelly K, Govindannagari R, Pandey S, Kompelli SK, Sheri V, Visarada KBRS, Kaul T* (2014) A modified CTAB method for efficient extraction of genomic DNA from Sorghum bicolor. Annals of Plant Sciences 3(7): 761-764

Kaul, T., Ram, B., Reddy, C.S., Bhatla, S.C., Reddy, M.K. (2014) Unravelling the regulation of somatic embryogenesis by extracellular calcium and auxin efflux blockers in hypocotyl explants of Albizzia lebbeck L.: a similarity in action. Inter J Bioassays 3(11), 3536-42.

Singh. J, Reddy, G. M., Aakrati, A., Chandrasekhar, K., Sopory, S.K., Kaul T. 2012. Molecular and structural analysis of C4-specific PEPC isoform from Pennisetum glaucum and its role in stress adaptation. Gene 500, 224-31.

Tripathy MK, Tyagi W, Kaul T, Deswal R, Reddy MK, Sopory SK 2012 Characterization and Functional Validation of Tobacco PLC-Delta for Abiotic Stress Tolerance. Plant Mol Biol Rep 30:488–497.

Reddy, P. S., Mallikarjuna G, Kaul, T, Chakradhar, T. Mishra, R. N., Sopory, S. K., Reddy, M. K. 2010. Molecular cloning and characterization of gene encoding for cytoplasmic Hsc70 from Pennisetum glaucum may playa protective role against abiotic stresses. Mol Genet Genomics 283, 243-54.

Shabrawi H. E., Kumar B., Kaul T., Reddy M. K., Pareek S. L. S., Sopory S. K. 2010. Redox homeostasis, antioxidant defense, and methylglyoxal detoxification as markers for salt tolerance in Pokkali rice. Protoplasma 245, 85-96

Mahanty, S., Kaul, T.*, Pandey P, Ramesha, A. R., Mallikarjuna, G., Reddy, C. S., Reddy, M. K., 2012. Molecular analysis of copper-zinc superoxide dismutase from Pennisetum glaucum reveals its role in stress adaptation. Gene 505:309-17

Kaul, T., Reddy, P. S., Mahanty, S., Thirulogachandar, V., Reddy, R. A., Kumar, B., Sopory, S. K., Reddy, M. K. 2011. Biochemical and molecular characterization of stress-induced b-carbonic anhydrase from a C4 plant, Pennisetum glaucum. J Plant Physiol 168, 601-610.

Mallikarjuna, G., Mallikarjuna, K., Kaul, T*. 2011. Expression of OsDREB2A transcription factor confers enhanced dehydration and salt stress tolerance in rice (Oryza sativa L.) Biotechnol Lett 33, 1689-97

ICGEB New Delhi

ICGEB Campus
Aruna Asaf Ali Marg
110 067 New Delhi
INDIA
Tel: +91-11-26741358/1007
Fax: +91-11-26742316
icgebicgeb.res.in

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