Research Groups

Sujatha Sunil

Vector Borne Diseases

Group Leader

Research Interests and Description

Sujatha Sunil

E-mail:  sujathaicgeb.res.in

Education

Madras University, MSc, 1994
MGR Medical University, PhD, 2000

Career History

Since 2016, Group Leader, Vector Borne Disease Group, International Centre for Genetic Engineering and Biotechnology, ICGEB New Delhi, India
2012, Visiting Scientist, University of Texas Medical Branch, Galveston, Texas, USA
2010-2015 Research Scientist (Ramanujan Fellow), Insect Resistance Group, ICGEB New Delhi, India
2007-2010 Research Scientist, Clininvent Pvt Ltd., New Delhi
Adjunct Faculty, Institute of Molecular Medicine, New Delhi
2004-2007 Postdoc, ICGEB New Delhi
2001-2004 Research Associate, National Institute of Malaria Research, New Delhi
2000-2001 Research Scientist, All India Institute of Medical Sciences, New Delhi

Scientific Activity

Research involves understanding the basis of pathogenesis in important vectors of India and devising transmission-blocking approaches to control vector borne diseases. She has two major focus research areas, namely virus evolution and host/vector-pathogen interactions.

Preliminary work on studying evolution of chikungunya virus in our country revealed the emergence of a new molecular signature in Indian isolates. Work is underway to study the effect of these mutations on pathogenicity of the virus and its virulence. Using high-throughput Next Generation Sequencing platforms and computational biology approaches, her lab is involved in understanding the impact of pathogen development on insect miRNome, insect immunity and redox cascade. Her work on insect small RNA population has provided important insights to the role of microRNAs in pathogenesis and insect immunity. She is currently working on deciphering the role of viral RNAi suppressors and insect defense and the impact of co-infection of chikungunya with dengue in both vector and host.

Selected publications

Kaur N, Jain J, Kumar A, Narang M, Zakaria MK, Marcelo A, Kumar D, Gaind R, Sunil S*. Chikungunya outbreak in Delhi, India, 2016: A Report on the co-infection status and co-morbid conditions in patients. 2017. New Microbes New Inf. 2017. https://doi.org/10.1016/j.nmni.2017.07.007 

Jain J, Nayak K, Tanwar N, Gaind R, Gupta B, Shastri JS, Bhatnagar RK, Murali Krishna Kaja MK, Chandele A, Sunil S. Clinical, Serological and Virological analysis of 572 chikungunya patients during the years 2010-2013 from India. Clin Infect Dis. 2017 Apr 1. doi: 10.1093/cid/cix283.

Jain J, Dubey SK, Jatin Shrinet J and Sunil.S. Dengue Chikungunya co-infection: A live-in relationship?? Biochem Biophy Res Comm. 2017. Feb 9. doi: 10.1016/j.bbrc.2017.02.008.

Shrinet J, Srivastava, P and Sunil S. Transcriptome analysis of Aedes aegypti in response to mono-infections and co-infections of Dengue virus-2 and Chikungunya virus. Biochem Biophys Res Commun. 2017 Feb 1. doi: 10.1016/j.bbrc.2017.01.162.

Mathur K, Anand A, Dubey SK, Sanan-Mishra N, Bhatnagar RK, Sunil S*. Analysis of chikungunya virus proteins reveals that non-structural proteins nsP2 and nsP3 exhibit RNA interference (RNAi) suppressor activity. Sci Rep. 2016 Nov 30.

Shrinet J, Shastri JS, Gaind R, Bhavesh NS, Sunil S*. Serum metabolomics analysis of patients with chikungunya and dengue mono/co-infections reveals distinct metabolite signatures in the three disease conditions. Sci Rep. 2016 Nov 15;6:36833. doi: 10.1038/srep36833.

Jain J, Kushwah RBS, Singh SS, Sharma A, Adak T, Singh OP, Bhatnagar RK, Subbarao SK, Sunil S*. Evidence For Natural Vertical Transmission Of Chikungunya Viruses In Field Populations Of Aedes Aegypti In Delhi And Haryana States In India. Acta Tropica. 2016 Jun 6

Jain J, Mathur K, Shrinet J, Bhatnagar RK, Suni S*. Analysis of coevolution in nonstructural proteins of Chikungunya Virus. Virology J 2016. Jun 2;13(1):86

Shrinet J, Agrawal A, Bhatnagar RK, Sunil S. Analysis of the genetic divergence in Asian strains of ZIKA virus with reference to 2015-2016 outbreaks. [Submitted]. Bull World Health Organ. E-pub: 22 Apr 2016. doi: http://dx.doi.org/10.2471/BLT.16.176065

Londhey, V., Aggarwal, S, Vaidya, N., Shastri, JS., Sunil, S. 2016. Chikungunya and dengue co-infections-the inside story. Journal of Assoc. Physicians India In press

Jain, S., Shrinet, J., Tridibes, A., Bhatnagar, R.K.,  Sunil, S. 2015. miRNA-mRNA conflux regulating immunity and oxidative stress pathways in the midgut of blood fed Anopheles stephensi. Non-Coding RNA 2015 1, 222-245

Jain, S., Rana, V., Tridibes, A., Sunil, S., Bhatnagar, R.K. 2015.  Dynamic expression of miRNAs across immature and adult stages of the malaria mosquito Anopheles stephensi. Parasite Vectors 8, 179 PubMed link

Shrinet, J., Nandal, UK., Adak, T., Bhatnagar, RK., Sunil, S. 2014. Inference of the oxidative stress network in Anopheles stephensi upon Plasmodium infection. PLoS One 9, e114461 PubMed link

Jain, S., Rana, V., Shrinet, J., Sharma, A., Tridibes, A., Sunil, S., Bhatnagar, R.K. 2014. Blood feeding and Plasmodium infection alters the miRNome of Anopheles stephensi. PLoS ONE 9, e98402 PubMed link

Shrinet, J., Jain, S., Jain, J., Bhatnagar, R.K., Sunil, S. 2014. Next Generation Sequencing reveals regulation of distinct microRNAs of Aedes during chikungunya virus development. PLoS Negl Trop Dis 8, e2616, doi:10.1371/journal.pntd.0002616 PubMed link

Sunil S, Singh OP, Nanda N, Raghavendra K, Reddy BPN, Subbarao SK. Analysis of population genetic structure of Indian Anopheles culicifacies species A using microsatellite markers. Parasites & Vectors, 2013, 6:166.

Shrinet J, Jain S, Sharma A, Singh SS, Mathur K, Rana V, Bhatnagar RK, Gupta B, Gaind R, Deb M, Sunil S*. Genetic characterization of Chikungunya virus from New Delhi reveal emergence of a new molecular signature in Indian isolates. Virology Journal, 2012, 9:100.

Londhey, V., Aggarwal, S, Vaidya, N., Shastri, JS., Sunil, S. 2016. Chikungunya and dengue co-infections-the inside story. Journal of Assoc. Physicians India (In press)

Kushwah, R.B.S., Jain, J., Sharma, A., Bhatnagar, R.K., Subbarao, S.K., Sunil, S. 2015. Co-Habitation and Concurrent Infection of Dengue and Chikungunya Viruses in Aedes Aegypti Field Populations from India. J Trop Dis, 4: 1-4

Jain, S., Shrinet, J., Tridibes, A., Bhatnagar, R.K., Sunil, S. 2015. miRNA-mRNA conflux regulating immunity and oxidative stress pathways in the midgut of blood fed Anopheles stephensi. Non-Coding RNA, 1: 222-245

Jain, S., Rana, V., Tridibes, A., Sunil, S., Bhatnagar, R.B. 2015. Dynamic expression of miRNAs across immature and adult stages of the malaria mosquito Anopheles stephensi. Parasite & Vectors. 8:179. PubMed link

Shrinet, J., Nandal, UK., Adak, T., Bhatnagar, RK., Sunil, S. 2014. Inference of the oxidative stress network in Anopheles stephensi upon Plasmodium infection. PLoS One. 9:e114461.

Jain, S., Rana, V., Shrinet, J., Sharma, A., Tridibes, A., Sunil, S., Bhatnagar, R.K. 2014. Blood feeding and Plasmodium infection alters the miRNome of Anopheles stephensi. PLoS ONE. 9:e98402.

Shrinet, J., Jain, S., Jain, J., Bhatnagar, R.K., Sunil, S. 2014. Next Generation Sequencing reveals regulation of distinct microRNAs of Aedes during chikungunya virus development. PLoS Negl Trop Dis, 8: e261. PubMed link

Sunil, S., Singh, O.P., Nanda, N., Raghavendra, K., Reddy, B.P.N., Subbarao, S.K. 2013. Analysis of population genetic structure of Indian Anopheles culicifacies species A using microsatellite markers. Parasites & Vectors, 6:166.

Shrinet, J., Jain, S., Sharma, A., Singh, S.S., Mathur, K., Rana, V., Bhatnagar, R.K., Gupta, B., Gaind, R., Deb, M., Sunil, S. 2012. Genetic characterization of Chikungunya virus from New Delhi reveal emergence of a new molecular signature in Indian isolates. Virology Journal, 9:100. PubMed link

Shrinet, J., Jain, S., Jain, J., Bhatnagar, R.K.,Sunil, S. 2014. Next Generation Sequencing reveals regulation of distinct microRNAs of Aedes during chikungunya virus development. PLoS Negl Trop Dis 8, 1, e2616. PubMed link

Sunil, S., Singh, O.P., Nanda, N., Raghavendra, K., Niranjan Reddy, B.P., Subbarao, S.K. 2013. Analysis of population genetic structure of Indian Anopheles culicifacies species A using microsatellite markers. Parasites and Vectors 6, 166

Shrinet, J., Jain, S., Sharma, A., Singh, S.S., Mathur, K., Rana, V., Bhatnagar, R.K., Gupta, B., Gaind, R., Deb, M., Sunil, S. 2012. Genetic characterization of Chikungunya virus from New Delhi reveal emergence of a new molecular signature in Indian isolates. Virol J 9, 100 PubMed link

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