Research Groups

Shashi Kumar

Metabolic Engineering

Group Leader

Research Interests and Description
Group Members

Shashi Kumar

International Centre for Genetic Engineering and Biotechnology
Aruna Asaf Ali Marg
110 067 New Delhi, India

E-mail: skrhodeicgeb.res.in, shashirhode@gmail.com
Office tel: +91-11-26741358/26742357 ext 475
Mobile: +91-99-99950544

Education

University of Delhi South Campus, Department of Genetics, New Delhi, India, PhD, 1998
India Institute of Technology (IIT), Biosciences and Biotechnology, MSc, 1991
Meerut University, Zoology, Botany, Chemistry, BSc, 1988

Career History

2016, Group Leader, Integrative Biology: Metabolic Engineering, International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi, India
2011-2015, Team Leader in advanced bio-energy research, Synthetic Biology and Biofuel Group, ICGEB, New Delhi, India
2009-2011, Research Scientist, Malaria Group, ICGEB New Delhi, India
2006-2009, Scientist, Yulex Corporation and USDA, Albany, CA, USA
2005-2006, Research Specialist, UC Berkeley, CA, USA
2001-2005, Research Associate, UCF, FL, USA
1998-2001, Research Associate, University of Virginia, Charlottesville, USA

Scientific Activity

  • Synthetic biology and Metabolic engineering of plant and algae
  • Chloroplast genome engineering
  • Terpenoid drugs biosynthesis in plants
  • Development of sustainable algae biofuel/biodiesel
  • Remediation of wastewater by algae
  • Chloroplast RNAi mediated cotton protection
  • Genome editing

Selected publications

Kaushik P, Kumar S (2018) Transcriptome Analysis of Bael (Aegle marmelos (L.) Corr.) a Member of Family Rutaceae. Forests, 9(8): 450 http://www.mdpi.com/1999-4907/9/8/450

Adeniran AA, Sonibare MA, Rajacharya GH, Kumar S (2018) Assessment of genetic fidelity of Dioscorea bulbifera L. and Dioscorea hirtiflora Benth and medicinal bioactivity produced from the induced tuberous roots. Plant Cell Tiss Organ Cult. 132: 343-357 https://link.springer.com/article/10.1007/s11240-017-1334-0

Singh AK, Sharma N, Farooqi H, Abdin MZ, Mock T, Kumar S (2017) Phycoremediation of municipal wastewater by microalgae to produce biofuel. International J Phytoremediation. 19(9): 805-812 https://www.ncbi.nlm.nih.gov/pubmed/28156133

Kunrunmi O, Adesalu T, Kumar S (2017). Genetic identification of new microalgal species from Epe Lagoon of West Africa accumulating high lipids. Algal Research, 22: 68-78 https://www.sciencedirect.com/science/article/pii/S2211926416307548

Malhotra K, Subramaniyan M, Rawat K, Kalamuddin M, Qureshi MF, Malhotra P, Mohmmed A, Cornish K, Daniell H, Kumar S (2016). Compartmentalized metabolic engineering for artemisinin biosynthesis and effective malaria treatment by oral delivery of plant cells. Molecular Plant, 9(11): 1464-1477 https://www.ncbi.nlm.nih.gov/pubmed/27773616

Singh, D., Kumar, S., Daniell, H. (2016) Expression of Beta-glucosidase increases trichome density and artemisinin content in transgenic Artemisia annua plants. Plant Biotechnology Journal, 16: 1034-1045 https://www.ncbi.nlm.nih.gov/pubmed/26360801

Ahmad, I., Sharma, A., Daniell, H., Kumar, S. (2015) Altered Lipid Composition and Enhanced Lipid Production in Microalga by Introduction of Brassica Diacylglycerol Acyltransferase 2. Plant Biotechnology Journal, 13: 540-550 https://www.ncbi.nlm.nih.gov/pubmed/25403771

Turan, S., Cornish, K., Kumar, S. (2014) Highly efficient callus-mediated genetic transformation of Parthenium argentatum Gray, an alternate source of latex and rubber. Industrial Crops and Products 62, 212-218 https://pubag.nal.usda.gov/catalog/5428639

Shao, M., Kumar, S., Thomson, J.G. (2014) Precise excision of plastid DNA by the large serine recombinase Bxb1. Plant Biotechnology Journal 12, 322-329 https://www.ncbi.nlm.nih.gov/pubmed/24261912

Truan, S., Kumar, S. Cornish, K., (2014) Photosynthetic response of in vitro guayule plants in low and high lights and the role of non-photochemical quenching in plant acclimation. Industrial Crops and Products 54, 266–271 https://www.sciencedirect.com/science/article/pii/S0926669014000296

Heikrujam, M., Kumar, D., Kumar, S., Gupta, S.C., Agrawal, V.  (2014) High efficiency cyclic production of secondary somatic embryos and ISSR based assessment of genetic fidelity among the emblings in Calliandra tweedii (Benth.). Scientia Hort, 177, 63-70 https://www.sciencedirect.com/science/article/pii/S0304423814004208

Saxena, B., Subramaniyan, M., Malhotra, K., Bhavesh, N.S., Potlakayala, S.D., Kumar, S. 2014. Metabolic engineering of chloroplasts for artemisinic acid biosynthesis and impact on plant growth. J Biosci 39, 1-9 https://www.ncbi.nlm.nih.gov/pubmed/24499788

Ahmad, I., Fatma, Z., Yazdani, S., Kumar, S. (2013) DNA barcode and lipid analysis of new marine algae potential for biofuel. Algal Research. 2, 10-15 https://www.sciencedirect.com/science/article/pii/S2211926412000525

Kumar, S., Baidoo, E., Hahn, F.M., Kahlon, T., Wood, D., McMahan, M.C., Cornish, K., Keasling, J., Daniell, H., Whalen, M.C. (2012) Remodeling the isoprenoid pathway in tobacco by expressing the cytoplasmic mevalonate pathway in chloroplasts. Metabolic Engineering 14: 19-2 https://www.ncbi.nlm.nih.gov/pubmed/22123257

Turan, S., Cornish K., Kumar, S. (2012) Salinity Tolerance in Plants: Breeding and Genetic Engineering. Australian Journal of Crop Science 6: 1337-1348 https://search.informit.com.au/documentSummary;dn=732395810014158;res=IELHSS

Singh, D., Singh, P.K., Chaudhary, S., Mehla, K., Kumar, S. (2012) Exome sequencing and advances in crop improvement. Advances in Genetics 79, 87-121https://www.ncbi.nlm.nih.gov/pubmed/22989766

Kumar, S., Kahlon, T and Chaudhary, S. (2011) DNA barcodes for unmasking the adulteration in olive oil. Food Chemistry 127: 1335–1341 https://www.ncbi.nlm.nih.gov/pubmed/25214135

Kumar, S., McMahan, M.C., Cornish, K. and Whalen, M.C. (2009) Comparative analysis of the complete sequence of the plastid genome of Parthenium argentatum and identification of DNA barcodes to differentiate Parthenium species and lines. BMC Plant Biology 2009, 9:131 https://www.ncbi.nlm.nih.gov/pubmed/19917140

Daniell, H., Kumar, S. and Dufourmantel, N. (2005) Breakthrough in chloroplast genetic engineering of agronomically important crops. Trends in Biotechnology 23: 238-245 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3486632/

Daniell, H., Chebolu, S., Kumar, S., Singleton, M., Falconer, R. (2005). Chloroplast-derived vaccine antigens and other therapeutic proteins. Vaccine 23:1779-1783 https://www.ncbi.nlm.nih.gov/pubmed/15734040

Kumar, S., Dhingra, A. and Daniell, H. (2004) Plastid expressed betaine aldehyde dehydrogenase gene in carrot cultured cells, roots and leaves confers enhanced salt tolerance. Plant Physiology 136: 2843-2854 https://www.ncbi.nlm.nih.gov/pubmed/15347789

Kumar, S., Dhingra, A. and Daniell, H. (2004) Stable transformation of the cotton plastid genome and maternal inheritance of transgenes. Plant Molecular Biology 56: 203-216 https://www.ncbi.nlm.nih.gov/pubmed/15604738

Kumar, S. and Timko, M.P. (2004) Enhanced Tissue-Specific Expression of the Herbicide Resistance bar Gene in Transgenic Cotton (Gossypium hirsutum L cv. Coker 310FR) Using the Arabidopsis rbcS ats1A Promoter. Plant Biotechnology 21: 251-260 https://www.jstage.jst.go.jp/article/plantbiotechnology/21/4/21_4_251/_article

Kumar, S. and Daniell, H. (2004) Engineering the chloroplast genome for hyper-expression of human therapeutic proteins and vaccine antigens in Recombinant Protein Protocols. Methods in Molecular Biology 267: 365-383 https://www.ncbi.nlm.nih.gov/pubmed/15269437

Patents

Kumar, S., Singh, A.K. Method of Utilization of Carbon Concentration Mechanism in Micro-Algal Species to Increase Production of Lipids and Obtain Bio-Fuel. Indian Patent Application No: 2856/DEL/2015

Kang, B., McMahan, C.M., Whalen, M.C., Dong, N., Kumar, S. (2016). Engineering rubber production in plants. US 20140325699 (granted). WO/2014/152747 https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2014152747

 

 

ICGEB New Delhi

ICGEB Campus
Aruna Asaf Ali Marg
110 067 New Delhi
INDIA
Tel: +91-11-26741358/1007
Fax: +91-11-26742316
icgebicgeb.res.in

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