Research Groups

Renu Tuteja

Mammalian Biology: Malaria

Group Leader

Research Interests and Description

Renu Tuteja

International Centre for Genetic Engineering and Biotechnology
Aruna Asaf Ali Marg
110 067 New Delhi, India

E-mail: renuicgeb.res.in
Office tel: +91-11-26742357
Office fax: +91-11-26742316

Education

Department of Chemistry, University of Kanpur, India, PhD, 1983
Department of Biochemistry, University of Lucknow, India, MSc, 1977
Faculty of Science, University of Lucknow, India, BSc, 1975

Career History

2000-present: Staff Research Scientist, Malaria Laboratory, ICGEB New Delhi, India
1995-1999: Assistant Scientist, ICGEB New Delhi, India 
1988-1995: Assistant Research Scientist, Molecular Pathology Laboratory, ICGEB Trieste, Italy
1986-1988: Postdoctoral Fellow, UCLA, Los Angeles, California, USA
1984-1986: Visiting Scientist, NIH (NICHHD), Bethesda, Maryland, USA

Scientific Activity

In order to understand the basic biology of the malaria parasite my group is working on the factors involved in the DNA/RNA transactions such as replication and repair etc. and we are also interested in studying the protein translation and protein translocation pathways of the parasite. We are characterizing some of the parasite specific proteins involved in various pathways. Understanding these mechanisms would provide basis for designing strategies to target them and control malaria. Based on our work in last few years a number of genes have been annotated in PlasmoDB. Some of these have been biochemically characterized.

Selected publications

Tuteja R. In silico analysis of Plasmodium species specific UvrD helicase. Communicative & Integrative Biology 2013, 6:2, e23125.

Ahmad M., and Tuteja R. Plasmodium falciparum RuvB1 is an active DNA helicase and translocates in the 5'-3' direction. Gene, 2013, 515, 99–109.

Ahmad M., Ansari A., Tarique M., Satsangi A.T., and Tuteja R. Plasmodium falciparum UvrD helicase translocates in 3' to 5' direction, colocalizes with MLH and modulates its activity through physical interaction. PLOS One 2012, 7(11): e49385. doi:10.1371/journal.pone.0049385

Ansari A., and Tuteja R. Genome wide comparative comprehensive analysis of Plasmodium falciparum MCM family with human host. Communicative & Integrative Biology, 2012, 5:6: 607-15.

Ahmad M., Singh S., Afrin F., and Tuteja, R. Novel RuvB nuclear ATPase is specific to intraerythrocytic mitosis during schizogony of Plasmodium falciparum. Mol. Biochem. Parasitol, 2012, 185, 58– 65.

Tarique M., Satsangi A.T., Ahmad M., Singh S. and Tuteja R. Plasmodium falciparum MLH is schizont stage specific endonuclease. Mol. Biochem. Parasitol, 2012, 181, 153– 161.

Ahmad M. and Tuteja R. Plasmodium falciparum RuvB proteins: Emerging importance and expectations beyond cell cycle progression.  Communicative & Integrative Biology 2012, 5:4, 1–12.

Tuteja R., Ansari A., Anita, Suthar M. K. and Saxena J. K. Genome wide computational analysis of Brugia malayi helicases: A comparison with human host. Gene 2012, 499, 202–208.

Tuteja, R. Helicases involved in splicing from malaria parasite Plasmodium falciparum. Parasitology International 2011; 60:335-340.

Tuteja R., Ansari A. and Chauhan VS. Emerging functions of transcription factors in malaria parasite. J Biomed Biotechnol. 2011; 2011:461979.

Tajrishi, M.M., Tuteja, R. and Tuteja, N. Nucleolin: the most abundant multifunctional phosphoprotein of nucleolus. Communicative & Integrative Biology. 2011, 4, 3:1-9.

Umate, P., Tuteja, N. and Tuteja, R. Genome-wide comprehensive analysis of human helicases. Communicative & Integrative Biology. 2011; 4:118-37

Mehta, J., and Tuteja, R. Inhibition of unwinding and ATPase activities of Plasmodium falciparum Dbp5/DDX19 homologue. Communicative & Integrative Biology. 2011, 4, 3:1-5.

Tuteja R. and Pradhan, A. PfeIF4E and PfeIF4A colocalize and their double-stranded RNA inhibits Plasmodium falciparum proliferation. Communicative & Integrative Biology 2010;3:611-3.

ICGEB New Delhi

ICGEB Campus
Aruna Asaf Ali Marg
110 067 New Delhi
INDIA
Tel: +91-11-26741358/1007
Fax: +91-11-26742316
icgebicgeb.res.in

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