Research Groups
Protein Networks
Research Interests and Description
Group Leader: Michael P. Myers, PhDGroup Members
Research Interests
High throughput proteomics, mass spectrometry, signal transduction, protein-protein interactions, tumorigenesis
Description of Research
The goal of the laboratory is to understand how protein complexes regulate cellular behavior. Inside the cell the majority of proteins can be found in highly interactive networks. The architecture of these networks and how they change in response to the cellular environment is critical for the normal physiological functioning of the cell. In fact, these networks are responsible for the robustness and adaptability of living cells and perturbations to these networks result in pathological conditions such as cancer and neurological disorders. The laboratory uses high throughput mass spectrometry to gain insights into the protein interaction networks from a variety of normal and pathological conditions.Recent Publications
Tomaić, V., Gardiol, D., Massimi, P., Ozbun, M., Myers, M., Banks, L. 2008. Human and primate tumour viruses use PDZ binding as an evolutionarily conserved mechanism of targeting cell polarity regulators. Oncogene doi:onc2008365.Bish, R.A., Fregoso, O.I., Piccini, A., Myers, M.P. 2008. Conjugation of complex polyubiquitin chains to WRNIP1. Journal of Proteome Research 7, 3481-3489
Bish, R.A., Myers, M.P. 2007. Werner helicase interacting protein 1 (WRNIP1) binds polyubiquitin via its zinc finger domain. J Biol Chem.
Huang, Y., Myers, M.P., Xu, R.-M. 2006. Crystal structure of the HP1-EMSY complex reveals an unusual mode of HP1 binding. Structure 14, 703-712
Narita, M., Narita, M., Krizhanovsky, V., Nuñez, S., Chicas, A., Hearn, A.A., Myers, M.P., Lowe, S.W. 2006. A novel role for high-mobility group a proteins in cellular senescence and heterochromatin formation. Cell 126, 503-514
Duelli, D.M., Hearn, S., Myers, M.P., Lazebnik. Y. 2005. A primate virus generates transformed human cells by fusion. J Cell Biol. 171, 493-503
