Research Groups

Pawan Malhotra

Malaria Biology

Group Leader

Research Interests and Description

Pawan Malhotra

International Centre for Genetic Engineering and Biotechnology
Aruna Asaf Ali Marg
110 067 New Delhi, India

E-mail: pawanmicgeb.res.in
Office tel: +91-11-26742357
Office fax: +91-11-26742316

Education

Delhi University, Department of Zoology, New Delhi, India, MSc, 1981
Delhi University, Department of Zoology, New Delhi, India, PhD, 1988

Career History

Since 2016, Group Leader, Malaria Biology, International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi, India
1994-2015, Staff Research Scientist, ICGEB, New Delhi, India
1990-1994, Research Associate, North Western University, Chicago, IL, USA
1988-1990, Research Officer, IISC, Bangalore, India
1984-1987, Senior Research Fellow, University of Delhi
1982-1984, Junior Research Fellow, University of Delhi

Teaching Activity

ICGEB PhD Course work; more than 100 talks in India and abroad. Organising Conferences/Workshops, participating faculty in EU programme, work in Dr. Andy Waters Lab, Leiden, The Netherlands, for malaria transfection. Participating Faculty - US-India Joint Research Training Program in Infectious Diseases. 

Scientific Activity

Plasmodium falciparum is a widespread protozoan parasite that causes malaria and is responsible for over a million deaths annually. Our primary focus has been to understand the process of hemoglobin trafficking and its degradation in the parasite food vacuole. We are currently working on leads for new drug development against drug-resistant strains of P. falciparum.

Member of DBT Task Force, RNAi, Member, National Academy of Sciences, Allahabad, India, Member of Academic Planning Board of Chaudhary Bansi Lal University, Bhiwani, Haryana, India.

Selected publications

Iyer, G.R., Singh, S., Kaur, I., Agarwal, S., Siddiqui, M.A., Bansal, A., Kumar, G., Saini, E., Paul, G., Mohmmed, A., Chitnis, C.E., Malhotra, P. 2018. Calcium-dependent phosphorylation of <i>Plasmodium falciparum</i> serine repeat antigen 5 triggers merozoite egress. J Biol Chem. 293, 9736-9746. doi: 10.1074/jbc.RA117.001540 PubMed link

Prakash, P., Zeeshan, M., Saini, E., Muneer, A., Khurana, S., Kumar Chourasia, B., Deshmukh, A., Kaur, I., Dabral, S., Singh, N., Anam, Z., Chaurasiya, A., Kaushik, S., Dahiya, P., Kalamuddin, M., Kumar Thakur, J., Mohmmed, A., Ranganathan, A., Malhotra, P. 2017. Human Cyclophilin B forms part of a multi-protein complex during erythrocyte invasion by Plasmodium falciparum. Nat Commun 8, 1548 doi: 10.1038/s41467-017-01638-6 PubMed link

Gupta, P., Mehrotra, S., Sharma, A., Chugh, M., Pandey, R., Kaushik, A., Khurana, S., Srivastava, N., Srivastava, T., Deshmukh, A., Panda, A., Aggarwal, P., Bhavesh, N.S., Bhatnagar, R.K., Mohmmed, A., Gupta, D., Malhotra, P. 2017. Exploring Heme and Hemoglobin Binding Regions of Plasmodium Heme Detoxification Protein for New Antimalarial Discovery. J Med Chem 60, 8298-8308 doi: 10.1021/acs.jmedchem.7b00089 PubMed link

Zeeshan, M., Kaur, I., Joy, J., Saini, E., Paul, G., Kaushik, A., Dabral, S., Mohmmed, A., Gupta, D., Malhotra, P. 2017. Proteomic Identification and Analysis of Arginine-Methylated Proteins of Plasmodium falciparum at Asexual Blood Stages. J Proteome Res. 16, 368-383. doi: 10.1021/acs.jproteome.5b01052 Pubmed link

Bhalla, K., Chugh, M., Mehrotra, S., Rathore, S., Tousif, S., Prakash Dwivedi V., Prakash, P., Kumar Samuchwal, S., Kumar, S., Kumar Singh, D., Ghanwat, S., Kumar, D., Das, G., Mohmmed, A., Malhotra, P., Ranganathan, A. 2015. Host ICAMs play a role in cell invasion by Mycobacterium tuberculosis and Plasmodium falciparum. Nature Communication. 6: 6049. PubMed link

Chugh, M., Sundararaman, V., Kumar, S., Reddy, V.S., Siddqui, W.A., Stuart, K.D. Malhotra, P. 2013. Protein complex directs hemoglobin-to-hemozoin formation in Plasmodium falciparum. Proc Natl Acad Sci U S A. 110: 5392-5397. PubMed link

ICGEB New Delhi

ICGEB Campus
Aruna Asaf Ali Marg
110 067 New Delhi
INDIA
Tel: +91-11-26741358/1007
Fax: +91-11-26742316
icgebicgeb.res.in

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