Research Groups

Pawan Malhotra

Malaria Biology

Group Leader

Research Interests and Description

Pawan Malhotra

International Centre for Genetic Engineering and Biotechnology
Aruna Asaf Ali Marg
110 067 New Delhi, India

E-mail: pawanmicgeb.res.in
Office tel: +91-11-26742357
Office fax: +91-11-26742316

Education

Delhi University, Department of Zoology, New Delhi, India, PhD, 1988
Delhi University, Department of Zoology, New Delhi, India, MSc, 1981

Career History

Since 1994, Staff Research Scientist, International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi, India
1990-1994, Research Associate, NorthWestern University, Chicago, USA
1988-1990, Research Officer, IISC, Bangalore, India

Scientific Activity

Plasmodium falciparum is a widespread protozoan parasite that causes malaria and is responsible for over a million deaths annually. Our primary focus has been to understand the process of hemoglobin trafficking and its degradation in the parasite food vacuole. We are currently working on leads for new drug development against drug-resistant strains of P. falciparum.

Selected publications

Bhalla, K., Chugh, M., Mehrotra, S., Rathore, S., Tousif, S., Prakash Dwivedi V., Prakash, P., Kumar Samuchwal, S., Kumar, S., Kumar Singh, D., Ghanwat, S., Kumar, D., Das, G., Mohmmed, A., Malhotra, P., Ranganathan, A. 2015. Host ICAMs play a role in cell invasion by Mycobacterium tuberculosis and Plasmodium falciparum. Nature Communication. 6: 6049. PubMed link

Kaderi Kibria, KM., Rawat, K., Klinger, CM., Datta, G., Panchal, M., Singh, S., Rajendran, G., Kaur, I., Sharma, V., Dacks, JB., Mohmmed, A., Malhotra, P. 2015. A role for adapter protein complex 1 in protein targeting to rhoptry organelles in Plasmodium falciparum. Biochem Biophys Acta- Mol Cell Research 1854: 699-710. PubMed link

Panchal, M., Rawat, K., Kumar, G., Kibria, K.M., Singh, S., Kalamuddin, Md, Mohmmed, A., Malhotra, P., Tuteja, R. 2014. Plasmodium falciparum signal recognition paticle components and anti-parasitic effect of ivermectin in blocking nucleo-cytoplasmic shuttling. Cell Death and Diseases. 5. e 994 PubMed link

Chug, M., Sundararaman, V., Kumar, S., Reddy, V.S., Siddqui, W.A., Stuart, K.D. Malhotra, P. 2013. Protein complex directs hemoglobin-to-hemozoin formation in Plasmodium falciparum. Proc Natl Acad Sci U S A. 110: 5392-5397. PubMed link

Ranjan, R., Chug, M., Kumar, S., Singh, S., Kanodia, S., Hossain, M.J., Korde, R., Grover, A., Dhawan, S., Chauhan, V.S., Reddy, V.S., Mohmmed, A and Malhotra, P. 2011. Proteome analysis reveals a large Merozoite Surface Protein-1 Associated Complex on the Plasmodium falciparum merozoite surface. J Prot Res. 10: 680-691. PubMed link

Singh, M., Mukherjee, P., Narayanasamy, K., Arora, R., Somdutta, Gupta, S., Natarajan, K., Malhotra, P. 2009. Proteome analysis of Plasmodium falciparum extracellular secretory antigens at asexual blood stages reveals a cohort of proteins with possible roles in immune modulation and signalling. Molecular and Cellular Proteomics 8: 2102-2118. PubMed link

 

ICGEB New Delhi

ICGEB Campus
Aruna Asaf Ali Marg
110 067 New Delhi
INDIA
Tel: +91-11-26741358/1007
Fax: +91-11-26742316
icgebicgeb.res.in

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