What's new in Neurobiology at ICGEB?
Highlights of recent activities by the ICGEB Neurobiology Lab in Trieste
The commitment of the Neurobiology Lab in Trieste to their scientific endeavours is no secret (thanks also to their early participation in the ice-bucket challenge); more in detail, here's a look at their recent achievements in their field of research:
ER response against TAU in Alzheimber's Disease
A common cause of neurodegeneration in Alzheimer's disease (AD), as well as other Frontotemporal Dementias, is the alteration in the solubility of the TAU protein. The Neurobiology Group has recently published a paper related to the conserved protein REEP1 that they have identified as being involved in the Endoplasmic Reticulum (ER) response against the accumulation of unfolded proteins like TAU. By increasing REEP1 activity, the Group managed to prevent the accumulation of unfolded TAU and the neurodegenerative process derived. Read more
In other recent papers in Neurobiol. Dis and Cell Reports, with studies performed in collaboration with the Versteken Group in Leuven, Belgium, the Group has characterized the initial defects in synaptic transmission occasioned by the conditional suppression of the ALS-associate protein TDP-43 in vivo. This, together with their finding that the normal neuronal activity can be recovered after long periods of TDP-43 dysfunction, indicates that late therapeutic interventions in ALS might be possible.
In July, F. Feiguin, Group Leader, spoke at the 9th FENS FORUM OF NEUROSCIENCE in Milan (programme), while the Group wishes to congratulate undergraduate student Marica Catinozzi, who has received a fellowship from the Max Planck Institute for Molecular Biomedicine and who will be leaving them shortly to continue her studies in Germany.