Repurposing drugs for anti-cancer therapeutics


In the 1 May online issue of Molecular Cancer Therapeutics, Luiz F Zerbini, Group Leader, Cancer Genomics Lab, in collaboration with Towia Libermann, Associate professor at Harvard Medical School and Director of the BIDMC Genomics, Proteomics and System Biology Center, applied a new individualized transcriptome analysis in conjunction with the Connectivity Map (C-MAP) database to reposition FDA-approved drugs for anti-cancer therapy. One of these drugs, pentamidine, slows tumor growth while enhancing survival, highlighting the potential of C-MAP analysis to repurpose drugs for anti-cancer therapy (PubMed link).

Further reading:

Bioinformatics Approach Identifies a New Use for an Old Drug

http://bidmc.org/News/In-Research/2014/May/Libermann.aspx

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