Published in the Journal of Virology and discussed on MD Magazine


Published this June in the Journal of Virology, A. Marcello, Molecular Virology Group and collaborators:

Hepatitis C virus NS5A targets the nucleosome assembly protein NAP1L1 to control the innate cellular response

As part of an international team of laboratories, headed by A. Marcello from ICGEB, the Molecular Virology Group has made a significant beakthrough in the study of Hepatitis C virus (HCV). Viruses have evolved to replicate and to overcome antiviral countermeasures of the infected cell. Hepatitis C virus is capable of establishing a lifelong chronic infection in the liver, which could develop into cirrhosis and cancer. Chronic viruses are particularly able to interfere with the cellular antiviral pathways by several different mechanisms. In this study, we identified a novel cellular target of the viral nonstructural protein NS5A and demonstrated its role in antiviral signaling. This factor is a nuclear chaperone involved in the remodeling of chromatin during transcription. When it is depleted, specific signaling pathways leading to antiviral effectors are affected. Therefore, we provide evidence for both a novel strategy of virus evasion from cellular immunity and a novel role for a cellular protein.

This research was undertaken thanks to the fundamental contribution by the Beneficentia Stiftung that financed the project.

Further reading:

MD Magazine: New Research HIghlights Role of Key Protein in HCV

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June 2017

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