Published this month in Nature Cell Biology

Published this month in Nature Cell Biology, L. Banks, Tumour Virology Group and collaborators:

Retriever is a multiprotein complex for retromer-independent endosomal cargo recycling

As part of an international team of laboratories, headed by Peter Cullen from the University of Bristol, the ICGEB Tumour Virology has made an important breakthrough in our understanding of the mechanisms by which Human Papillomaviruses infect the target cell. In this study, published in Nature Cell Biology and the subject of an accompanying News and Views article, the authors describe the identification of a new multi-protein complex that plays an important role in the recycling of proteins back to the cell surface. The incoming Human Papillomavirus, which is a major cause of human tumours, including cervical cancer, appears to hijack this complex, thereby ensuring that the virus can gain entry into the cell nucleus and initiate viral gene expression, eventually giving rise to the production of more infectious virus particles. This study therefore identifies potentially novel ways of blocking virus infections.

News and Views

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