ICGEB: What have we been publishing?

Read about recent findings from current research at ICGEB:

In the 12 March issue of Oncogene, a study led by Juliano Paccez, Postdoctoral fellow in the Cancer Genomics lab, and Luiz Zerbini, Group Leader, has revealed that the receptor tyrosine kinase Axl is consistently upregulated in metastatic prostate cancer cells and tumor samples and has uncovered a potential target for prostate cancer treatment.
The expression of Axl is deregulated in prostrate cancer and blockage of Axl gene expression causes inhibition of cell proliferation, migration and invasion and tumor growth in vivo. The discovery that Axl regulates the constitutively activated Akt/IKKα/NF-κB axis could guide researchers in designing drugs to specifically inhibit this receptor, thereby sending cancer cells to their death (link to PubMed).

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The Protein Structure and Bioinformatics Group's latest paper in Biochimica et Biophysica Acta on the PDZ-binding motif was published in June 2012 (link to PubMed), while the Molecular Immunology Group published on selective targeting of proteins within the secretory pathway for Endoplasmic Reticulum-Associated Degradation in JBC (link to PubMed). The latest results from the Molecular Hematology Group appeared in the May 2012 issue of Blood (link to PubMed).

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The Molecular Medicine Group recently published a paper in Human Gene Therapy (link to PubMed) on enhanced athletic performance; the misuse of gene transfer in sports to achieve better athletic perfomance, while escaping from traditional doping detection methods remains a hot topic, particularly on the eve of the Olympics.

Also recently published in Gene Therapy (link to PubMed) "VEGF gene therapy: therapeutic angiogenesis in the clinic and beyond", and in Molecular Vision "Vascular endothelial growth factor-B gene transfer exacerbates retinal and choroidal neovascularization and vasopermeability without promoting inflammation" (link to PubMed) .

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The Molecular Pathology Group's latest publications have featured Lorena Zubovic's work in Nucleic Acids Research (link to PubMed), which looks at mutually exclusive splicing through a combinatorial mechanism that involves three distinct splicing regulatory elements and their ligands and Emanuale Buratti's paper on exon skipping mutations in neurofibromatosis, in Methods in Molecular Biology (link to PubMed).

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