ICGEB New Delhi: new pathways for Tuberculosis therapy


A recent study undertaken by the Mammalian Biology: Immunology Group, in collaboration with the All India Institute of Medical Science, focuses on new pathways for TB therapy.

The findings, published in the journal Cell, concern the way the TB bacterium survives inside the human body. The results could be used to create a TB therapy that is not antibiotics-based and could be a valuable tool in the fight against antibiotic-resistant TB. [see PubMed link]

Kanury Rao, Group Leader of the Mammalian Biology: Immunology lab and his team isolated the 44 human proteins critical for TB's survival inside the human body. If scientists create a therapy that suppresses the production of these proteins, Rao says, public health officials could combine it with existing treatments to "hit TB from two sides at once".

Once considered a dead disease, like smallpox or bubonic plague, Tuberculosis has re-emerged as one of the major public health challenges of the century.


8 March 2010
Leading Edge, Minireview, Cell [PubMed link]

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