Research Groups

Naseem Gaur

Yeast Biofuel

Group Leader

Research Interests and Description

Group Members

Naseem A. Gaur

International Centre for Genetic Engineering and Biotechnology
DBT-ICGEB Center for Advance Bioenergy Research
Aruna Asaf Ali Marg
110 067 New Delhi, India

E-mail: naseemicgeb.res.in , nasgaurhotmail.com
Office tel: +91-11-26741358 ext 452

Education

Jawaharlal Nehru University /Jamia Millia Islamia University New Delhi, Ph.D., 2005
Jamia Millia Islamia University, New Delhi, M.Sc. (Bio-Sciences), 1999
Jamia Millia Islamia University, New Delhi, B.Sc. (Bio-Sciences), 1997

Career History

2012- Present: Research Scientist and Ramanujan Fellow, Synthetic Biology and Biofuel Group, DBT-ICGEB Center for Advance Bioenergy Research, ICGEB New Delhi, India
2010-2012: Research Fellow, National Institutes of Health (NIH), Bethesda, Maryland, USA
2007-2010: Postdoctoral Research Fellow, National Institutes of Health (NIH), Bethesda, Maryland, USA
2005- 2007: Post-doctoral Research Fellow, BWH, Harvard University, Boston, MA, USA

Teaching Activity

Tutoring activities in the ICGEB PhD Programme    

Scientific Activity

Current research interest focuses on the development of novel strains for second generation biofuels production, with special emphasis on yeast, Surface display of enzymes and consolidated bioprocessing. Monocomponent cellulase production and development of novel cocktails for deconstruction of lignocellulosic biomass.  He also maintains a strong interest in the field of multidrug resistance in human fungal pathogens.

Research activity is funded through grants from various public and private bodies, including the Department of Science and Technology (DST) and Department of Biotechnology (DBT), Ministry of Science and Technology, Government of India.
Naseem Gaur regularly reviews scientific manuscripts for international journals in the fields of biofuels, Gene expression, multidrug resistance and grant applications in the context of biotechnology. Over 15 papers in peer-reviewed international journals and 5 reviews or chapters in published books. He regularly presents his research activity at meetings and seminars worldwide.

Selected publications

Dubey, R., Jakeer, S., Gaur, N. A.* (2015) Screening of natural yeast isolates under the effects of stresses associated with second-generation biofuel production. J Biosci Bioeng. Oct 16. pii: S1389-1723(15)00337-0. doi: 10.1016/j.jbiosc.2015.09.006

Pirzadah, T., Garg, S., Singh, J., Vyas, A., Kumar, M., Gaur, N., Bala, M., Rehman, R., Varma, A., Kumar, V., Kumar, M.*  (2014) Characterization of Actinomycetes and Trichoderma spp. for cellulase production utilizing crude substrates by response surface methodology. SpringerPlus, 3:622

Gaur NA, Hasek J, Garvey Brickner D, Qiu H, Zhang F, Wong CM, Malcova I, Vasicova P, Brickner JH, Hinnebusch A. (2013). Vps Factors are Required for Efficient Transcription Elongation in Budding Yeast. Genetics. Mar;193(3):829-51.

(An education primer published on this article written by Andrea A. Duina, Biology Department, Hendrix College, Conway, Arkansas 72032 entitled " New Roles for Old Characters: An Educational Primer for Use with “Vps Factors Are Required for Efficient Transcription Elongation in Budding Yeast” Genetics, 2013, Vol. 194, 27–33 )

Qiu, H. Hu, C., Gaur, N. A., and Hinnebusch, A. G., (2012). Pol II CTD kinases Bur1 and Kin28 promote Spt5 CTR-independent recruitment of Paf1 complex. EMBO J. 2012 Aug 15;31(16):3494-505.

Mousley, C. J. Yuan, P., Gaur, N. A., Trettin  K. D., Nile, A. H., Dewar, B., Deminoff, S., Herman, P.K., Hinnebusch, A. G., Macdonald, J. M., and Bankaitis, V. A., (2012). A sterol binding protein integrates endosomal lipid metabolism with TOR signaling and nitrogen sensing. CELL,  Volume 148, Issue 4, 702-715

Chu, J. Loughlin, E, A., Gaur, N.A., Banerjee, S. S., Ding, Y., Monson, C., Ukomadu, C., and Sadler, K.C. (2011). UHRF1 phosphorylation by Cyclin A2/CDK2 is required for zebrafish embryogenesis. Mol Biol Cell. Jan;23(1):59-70. Epub 2011 Nov 9

Gaur, N. A. Zhang, F., Hasek, J., Kim, S., Qiu, H., Swanson, M. J., and Hinnebusch, A. G., (2008). Disrupting Vesicular Trafficking at the Endosome Attenuates Transcriptional Activation by Gcn4. Mol Cell Biol. 28(22), 6796-818

Manoharlal, R. Gaur, N. A., Panwar, S. L., Morschhäuser, J., and  Prasad, R., (2008). Transcriptional activation and increased mRNA stability contribute to overexpression of CDR1 in azole-resistant Candida albicans. Antimicrobial Agents Chemother. 52(4), 1481-92

Sadler, K. C. Krahn, K. N., Gaur, N. A., and Ukomadu, C., (2007). Liver growth in the embryo and during liver regeneration in Zebrafish requires the cell cycle regulator, uhrf1. PNAS.(USA) 104(5), 1570-5

Saini, P. Gaur, N. A., and Prasad, R., (2006). Chimeras of ABC drug transporter Cdr1p reveal functional indispensability of transmembrane domains and nucleotide binding domains: transmembrane segment 12 is replaceable with similar homologous region of a non-drug transporter Cdr3p. Microbiology. 152(Pt 5), 1559-73

Prasad, R. Gaur, N. A., Gaur, A., and Komath, S. S., (2006). Efflux Pumps in Drug Resistance of Candida. Infectious Disorders-Drug Targets. 2, 69-83

Prasad, T. Saini, P., Gaur, N. A., Vishwakarma, R. A., Khan, L. A., Haq, Q. M. R., and Prasad, R., (2005). Functional analysis of CaIPT1, a sphingolipid biosynthetic gene involved in multidrug resistance and morphogenesis of Candida albicans. Antimicrob Agents Chemother. 49(8), 3442-52

Gaur, N. A. Manoharlal, R., Saini, P., Prasad, T., Mukhopadhyay, G., Hoefer, M., Morschhäuser, J., and Prasad, R., (2005). Expression of the CDR1 efflux pump in Clinical Candida albicans isolates is controlled by a negative regulatory element. BBRC. 332(1), 206-14

Saini1, P. Prasad, T., Gaur, N. A., Shukla, S., Jha, S., Komath, S. S., Haq, Q. M. R., Khan, L. A., and Prasad, R., (2005). Alanine scanning of transmembrane helix 11 of Cdr1p ABC antifungal efflux pump of Candida albicans: identification of amino acid residues critical for drug efflux. J Antimicrob Chemother. 56(1), 77-86. JIF:4.6

Gaur, N. A. Karnani, N., Jha, S., Puri, N., Murthy, S. K., Goswami, S. K., Mukhopadhyay, G., and Prasad, R., (2004). SRE1 and SRE2 Are Two Specific Steroid-Responsive Modules of Candida Drug Resistance Gene 1 (CDR1) Promoter. Yeast. 21(3), 219-39.

Gaur, N. A. Puri, N., Karnani, N., Mukhopadhyay, G., Goswami, S. K., and Prasad, R., (2004). Identification of a Negative Regulatory Element Which Regulates Basal Transcription of A Multi-drug Resistance Gene CDR1 of Candida albicans. FEMS Yeast Res. 4(4-5), 389-99.

ICGEB New Delhi

ICGEB Campus
Aruna Asaf Ali Marg
110 067 New Delhi
INDIA
Tel: +91-11-26741358/1007
Fax: +91-11-26742316
icgebicgeb.res.in

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