Research Groups

Molecular Medicine

Research Interests and Description
Group Members

Mauro Giacca

Director-General ICGEB
Group Leader

International Centre for Genetic Engineering and Biotechnology
Padriciano 99
34149 Trieste, Italy

E-mail: giacca@icgeb.org
Office tel: +39-040-3757324
Lab tel: +39-040-3757325
Office fax: +39-040-3757380

Education

Faculty of Medicine, University of Trieste, Italy, MD, 1984
Admitted to the Medical Doctors and Surgeons Register, 1985
University of Genova, Italy, PhD, 1989

Career History

Since July 2014, Director-General of the International Centre for Genetic Engineering and Biotechnology, ICGEB
2004-2014, Director of the Trieste Component, ICGEB Trieste, Italy.
2000-2004, Director of the Molecular Biology Laboratory of the Scuola Normale Superiore in Pisa, Italy.
Since 1995, Senior Scientist and Group Leader of the Molecular Medicine Laboratory of the ICGEB in Trieste.
1988-1994, Assistant Research Scientist at ICGEB, Trieste.
1986-1987, PhD student at the IGBE, CNR, Pavia.
1980-1985, Pre-doctoral student and fellow at the Institute of Microbiology of the University of Trieste.

Teaching Activity

Since 2005, Full Professor, University of Trieste.
2000-2005, Associate Professor of Molecular Biology at the Scuola Normale Superiore in Pisa.
Since 2001, external Professor in the course Gene Therapy at the Medical School at the University of Trieste.
1989-1999, external Professor in different courses of Microbiology and Medical Genetics at the Faculty of Medicine of the University of Trieste.
1991-1996, Lecturer in the PhD Course of Molecular Genetics of the International School for Advanced Studies (ISAS) of Trieste, Italy.

Scientific Activity

Current research interest focuses on the development of novel biotherapeutics for cardiovascular disorders, with special emphasis on the identification of growth factors and microRNAs able to induce new blood vessel formation and cardiac regeneration in patients with myocardial infarction or heart failure. He also maintains a strong interest in the molecular biology of HIV-1 infection.
Research activity is funded through grants from various public and private bodies, including the European Research Council (ERC Advanced Investigator Grants), the Italian Ministry for Education and Research, the World Antidoping Agency (WADA) Canada, the JDRF USA, the Telethon Foundation Italy, among others.
M. Giacca regularly reviews scientific manuscripts for international journals in the fields of gene therapy, cardiovascular disorders and HIV infection, and grant applications in the context of calls from the European Commission and various granting bodies throughout Europe and has published over 240 papers in peer-reviewed international journals and 20 reviews or chapters in published books and university text books. He is the author of the book "Gene Therapy", Springer ed., 2010. He regularly presents his research activity at meetings and seminars worldwide.

Selected publications

Giacca M on PubMed

Eulalio, A., Mano, M., Dal Ferro, M., Zentilin, L., Sinagra, G., Zacchigna, S., Giacca, M. 2012. Functional screening identifies microRNAs inducing cardiac regeneration. Nature doi:10.1038/nature11739, in press

Carrer, A., Moimas, S., Zacchigna, S., Pattarini, L., Zentilin, L., Ruozi, G., Mano, M., Sinigaglia, M., Maione, F., Serini, G., Giraudo, E., Bussolino, F., Giacca, M. 2012. Neuropilin-1 identifies a subset of bone marrow Gr1_ monocytes that can induce tumor vessel normalization and inhibit tumor growth. Cancer Res DOI:10.1158/0008-5472.CAN-12-0762, in press.

Meloni, M., Descamps, B., Caporali, A., Zentilin, L., Floris, I., Giacca, M., Emanueli, C. 2012. Nerve growth factor gene therapy using adeno-associated viral vectors prevents cardiomyopathy in type 1 diabetic mice. Diabetes 61, 229-40.

Maione, F., Capano, S., Regano, D., Zentilin, L., Giacca, M., Casanovas, O., Bussolino, F., Serini, G., Giraudo, E. 2012. Semaphorin 3A overcomes cancer hypoxia and metastatic dissemination induced by antiangiogenic treatment in mice. J Clin Invest 122, 1832-48.

Macedo, A., Moriggi, M., Vasso, M., De Palma, S., Sturnega, M., Friso, G., Gelfi, C., Giacca, M., Zacchigna, S. 2012. Enhanced Athletic Performance on Multisite AAV-IGF1 Gene Transfer Coincides with Massive Modification of the Muscle Proteome. Hum Gene Ther 23, 146-57.

Lovric, J., Mano, M., Zentilin, L., Eulalio, A., Zacchigna, S., Giacca, M. 2012. Terminal Differentiation of Cardiac and Skeletal Myocytes Induces Permissivity to AAV Transduction by Relieving Inhibition Imposed by DNA Damage Response Proteins. Mol Ther 20, 2087-97.

Giacca, M., Zacchigna, S. 2012. VEGF gene therapy: therapeutic angiogenesis in the clinic and beyond. Gene Ther 19, 622-9.

Giacca, M., Zacchigna, S. 2012. Virus-mediated gene delivery for human gene therapy. J Control Release 161, 377-88.

Bortolussi, G., Zentilin, L., Baj, G., Giraudi, P., Bellarosa, C., Giacca, M., Tiribelli, C., Muro, A.F. 2012. Rescue of bilirubin-induced neonatal lethality in a mouse model of Crigler-Najjar syndrome type I by AAV9-mediated gene transfer. FASEB J 26, 1052-63.

Katare, R., Caporali, A., Zentilin, L., Avolio, E., Sala-Newby, G., Oikawa, A., Cesselli, D., Beltrami, A.P., Giacca, M., Emanueli, C., Madeddu, P. 2011. Intravenous gene therapy with PIM-1 via a cardiotropic viral vector halts the progression of diabetic cardiomyopathy through promotion of prosurvival signaling. Circ Res 108, 1238-51.

Karvinen, H., Pasanen, E., Rissanen, T.T., Korpisalo, P., Vahakangas, E., Jazwa, A., Giacca, M., Yla-Herttuala, S. 2011. Long-term VEGF-A expression promotes aberrant angiogenesis and fibrosis in skeletal muscle. Gene Ther 18, 1166-72.

Giacca, M., Baker, A.H. 2011. Heartening results: the CUPID gene therapy trial for heart failure. Mol Ther 19, 1181-2.

Eulalio, A., Frohlich, K.S., Mano, M., Giacca, M., Vogel, J. 2011. A Candidate Approach Implicates the Secreted Salmonella Effector Protein SpvB in P-Body Disassembly. PLoS One 6, e17296.

Di Stefano, V., Giacca, M., Capogrossi, M.C., Crescenzi, M., Martelli, F. 2011. Knockdown of Cyclin-dependent Kinase Inhibitors Induces Cardiomyocyte Re-entry in the Cell Cycle. J Biol Chem 286, 8644-54.

Allouch, A., Di Primio, C., Alpi, E., Lusic, M., Arosio, D., Giacca, M., Cereseto, A. 2011. The TRIM Family Protein KAP1 Inhibits HIV-1 Integration. Cell Host Microbe 9, 484-95.

Giacca, M. 2010. Gene Therapy. Springer-Verlag

Giacca, M. 2010. Non-redundant functions of the protein isoforms arising from alternative splicing of the VEGF-A pre-mRNA. Transcription 1, 149-153

Mendoza-Maldonado, R., Paolinelli, R., Galbiati, L., Giadrossi, S., Giacca, M. 2010. Interaction of the retinoblastoma protein with Orc1 and its recruitment to human origins of DNA replication. PLoS One 5, e13720 PubMed link

Jablonski, J.A., Amelio, A.L., Giacca, M., Caputi, M. 2010. The transcriptional transactivator Tat selectively regulates viral splicing. Nucleic Acids Res. 38, 1249-1260 PubMed link

Lock, M., McGorray, S., Auricchio, A., et al. 2010. Characterization of a Recombinant Adeno-Associated Virus Type 2 Reference Standard Material. Hum Gene Ther 21, 1273-1285 PubMed link

Manganaro, L., Lusic, M., Gutierrez, M.I., Cereseto, A., Del Sal, G., Giacca, M. 2010. Concerted action of cellular JNK and Pin1 restricts HIV-1 genome integration to activated CD4(+) T lymphocytes. Nat. Med. 16, 329-333 PubMed link

Pepe, M., Mamdani, M., Zentilin, L., Csiszar, A., Qanud, K., Zacchigna, S., Ungvari, Z., Puligadda, U., Moimas, S., Xu, X., Edwards, J.G., Hintze, T.H., Giacca, M., Recchia, F.A. 2010. Intramyocardial VEGF-B167 gene delivery delays the progression towards congestive failure in dogs with pacing-induced dilated cardiomyopathy. Circ Res. 106, 1893-1903 PubMed link

Terreni, M., Valentini, P., Liverani, V., Gutierrez, M.I., Di Primio, C., Di Fenza, A., Tozzini, V., Allouch, A., Albanese, A., Giacca, M., Cereseto, A. 2010. GCN5-dependent acetylation of HIV-1 integrase enhances viral integration. Retrovirology 7, 18 PubMed link

Van de Veire, S., Stalmans, I., Heindryckx, F., et al. 2010. Further pharmacological and genetic evidence for the efficacy of PlGF inhibition in cancer and eye disease. Cell. 141, 178-190 PubMed link

Zentilin, L., Giacca, M. 2010. The renaissance of competitive PCR as an accurate tool for precise nucleic acid quantification. Methods Mol Biol. 630, 233-248 PubMed link

Zentilin, L., Puligadda, U., Lionetti, V., Zacchigna, S., Collesi, C., Pattarini, L., Ruozi, G., Camporesi, S., Sinagra, G., Pepe, M., Recchia, F.A., Giacca, M. 2010. Cardiomyocyte VEGFR-1 activation by VEGF-B induces compensatory hypertrophy and preserves cardiac function after myocardial infarction. FASEB J. 24, 1467-1478 PubMed link

Terreni, M., Valentini, P., Liverani, V., Gutierrez, M.I., Di Primio, C., Di Fenza, A., Tozzini, V., Allouch, A., Albanese, A., Giacca, M., Cereseto, A. 2010. GCN5-dependent acetylation of HIV-1 integrase enhances viral integration. Retrovirology 7, 18

Maione, F., Molla, F., Meda, C., Latini, R., Zentilin, L., Giacca, M., Seano, G., Serini, G., Bussolino, F., Giraudo, E. 2009. Semaphorin 3A is an endogenous angiogenesis inhibitor that blocks tumor growth and normalizes tumor vasculature in transgenic mouse models. J Clin Invest. 119, 3356-3372 PubMed link

Paolinelli, R., Mendoza-Maldonado, R., Cereseto, A., Giacca, M. 2009. Acetylation by GCN5 regulates CDC6 phosphorylation in the S phase of the cell cycle. Nat Struct Mol Biol. 16, 412-420  PubMed link

Tafuro, S., Ayuso, E., Zacchigna, S., Zentilin, L., Moimas, S., Dore, F., Giacca, M. 2009. Inducible adeno-associated virus vectors promote functional angiogenesis in adult organisms via regulated vascular endothelial growth factor expression. Cardiovasc Res. 83, 663-671  PubMed link

Cervelli, T., Palacios, J.A., Zentilin, L., Mano, M., Schwartz, R.A., Weitzman, M.D., Giacca, M. 2008. Processing of recombinant AAV genomes occurs in specific nuclear structures that overlap with foci of DNA-damage-response proteins. J Cell Sci 121, 349-357 PubMed link

Collesi C, Zentilin L, Sinagra G, Giacca M. 2008. Notch1 signaling stimulates proliferation of immature cardiomyocytes. J. Cell Biol. 183, 117-128  PubMed link

Giacca, M. 2008. Gene Therapy to Induce Cellular Resistance to HIV-1 Infection: Lessons from Clinical Trials. Adv Pharmacol 56, 297-325

Perkins, K.J., Lusic, M., Mitar, I., Giacca, M., Proudfoot, N.J. 2008. Transcription-Dependent Gene Looping of the HIV-1 Provirus Is Dictated by Recognition of Pre-mRNA Processing Signals. Mol. Cell. 29, 56-68  PubMed link

Sabo, A., Lusic, M., Cereseto, A., Giacca, M. 2008. Acetylation of conserved lysines in the catalytic core of CDK9 inhibits kinase activity and regulates transcription. Mol. Cell. Biol. 7, 2201-2012  PubMed link

Vardabasso, C., Manganaro, L., Lusic, M., Marcello, A., Giacca, M. 2008. The histone chaperone protein Nucleosome Assembly Protein-1 (hNAP-1) binds HIV-1 Tat and promotes viral transcription. Retrovirology 28, 5-8

Zacchigna, S., Ostli, E.K., Arsic, N., Pattarini, L., Giacca, M., Djurovic, S. 2008. A novel myogenic cell line with phenotypic properties of muscle progenitors. J. Mol. Med. 86, 105-115

Zacchigna, S., Pattarini, L., Zentilin, L., Moimas, S., Carrer, A., Sinigaglia, M., Arsic, N., Tafuro, S., Sinagra, G., Giacca, M. 2008. Bone marrow cells recruited through the neuropilin-1 receptor promote arterial formation at the sites of adult neoangiogenesis in mice. J. Clin. Invest. 118, 2062-207 PubMed link

Cardarelli, F., Serresi, M., Bizzarri, R., Giacca, M., Beltram, F. 2007. In vivo study of HIV-1 Tat arginine-rich motif unveils Its transport properties. Mol. Ther. 15, 1313-1322

Crotti, A., Lusic, M., Lupo, R., Lievens, P.M., Liboi, E., Chiara, G.D., Tinelli, M., Lazzarin, A., Patterson, B.K., Giacca, M., Bovolenta, C., Poli, G. 2007. Naturally occurring C-terminally truncated STAT5 is a negative regulator of HIV-1 expression. Blood 109, 5380-5389

Fisher, C., Jonckx, B., Mazzone, M., Zacchigna, S., Autiero, M., Chorianopoulos, E., Demol, M., Deparaetere, H., Wyns, S., Ngo, H., Pattarini, L., Plaisance, S., Dewerchin., M., Giacca, M., Moons, L., Stassen, J.-M., Collen, D., Carmeliet, P. 2007. A monoclonal anti-PlGF antibody inhibits tumor growth and lymphatic metastasis without affecting healthy vessels. Cell 131, 463-475

Giacca, M. 2007. Gene therapy to induce cellular resistance to HIV-1 infection: lessons from clinical trials. In: Advances in Pharmacology. HIV-1: Molecular Biology and Pathogenesis: Clinical Applications (K. Teh-Jeang, Ed.), Vol. 56, pp. Elsevier

Giacca, M. 2007. Virus-mediated gene transfer to induce therapeutic angiogenesis: where do we stand? Int. J. Nanomedicine 2, 527-540

Manasseri, B., Cuccia, G., Moimas, S., D'Alcontres, F.S., Polito, F., Bitto, A., Altavilla, D., Squadrito, F., Geuna, S., Pattarini, L., Zentilin, L., Collesi, C., Puligadda, U., Giacca, M., Colonna, M.R. 2007. Microsurgical arterovenous loops and biological templates: a novel in vivo chamber for tissue engineering. Microsurgery 27, 623-629

Messina, S., Mazzeo, A., Bitto, A., Aguennouz, M., Migliorato, A., De Pasquale, M.G., Minutoli, L., Altavilla, D., Zentilin, L., Giacca, M., Squadrito, F., Vita, G. 2007. VEGF overexpression via adeno-associated virus gene transfer promotes skeletal muscle regeneration and enhances muscle function in mdx mice. Faseb J 21, 3737-3746

Ramirez, Y.J., Tasciotti, E., Gutierrez-Ortega, A., Torres, A.J., Flores, M.T., Giacca, M., Lim, M.A. 2007. Fruit-specific expression of the human immunodeficiency virus type 1 tat gene in tomato plants and its immunogenic potential in mice. Clin Vaccine Immunol 14, 685-692

Schwartz, R.A., Palacios, J.A., Cassell, G.D., Adam, S., Giacca, M., Weitzman, M.D. 2007. The Mre11/Rad50/Nbs1 complex limits adeno-associated virus transduction and replication. J. Virol. 81, 12936-12945

Zacchigna, S., Tasciotti, E., Kusmic, C., Arsic, N., Sorace, O., Marini, C., Marzullo, P., Pardini, S., Petroni, D., Pattarini, L., Moimas, S., Giacca, M., Sambuceti, G. 2007. In vivo imaging shows abnormal function of vascular endothelial growth factor-induced vasculature. Hum. Gene Ther. 18, 515-524

Zentilin, L., Giacca, M. 2007. Competitive PCR for precise nucleic acid quantification. Nat. Protoc. 2, 2092-2104

Benigni, A., Tomasoni, S., Turka, L.A., Longaretti, L., Zentilin, L., Mister, M., Pezzotta, A., Azzollini, N., Noris, M., Conti, S., Abbate, M., Giacca, M., Remuzzi, G. 2006. Adeno-Associated Virus-Mediated CTLA4Ig Gene Transfer Protects MHC-Mismatched Renal Allografts from Chronic Rejection. J. Am. Soc. Nephrol. 17, 1665-1672

Ferrarini, M., Arsic, N., Recchia, F.A., Zentilin, L., Zacchigna, S., Xu, X., Linke, A., Giacca, M., Hintze, T.H. 2006. Adeno-associated virus-mediated transduction of VEGF165 improves cardiac tissue viability and functional recovery after permanent coronary occlusion in conscious dogs. Circ. Res. 98, 954-961

Pegoraro, G., Marcello, A., Myers, M.P., Giacca, M. 2006. Regulation of Adeno-Associated Virus DNA Replication by the Cellular TAF-I/Set Complex. J Virol 80, 6855-6864

Secchiero, P., Candido, R., Corallini, F., Zacchigna, S., Toffoli, B., Rimondi, E., Fabris, B., Giacca, M., Zauli, G. 2006. Systemic tumor necrosis factor-related apoptosis-inducing ligand delivery shows antiatherosclerotic activity in apolipoprotein E-null diabetic mice. Circulation 114, 1522-1530

Zentilin, L., Tafuro, S., Zacchigna, S., Arsic, N., Pattarini, L., Sinigaglia, M., Giacca, M. 2006. Bone marrow mononuclear cells are recruited to the sites of VEGF-induced neovascularization but are not incorporated into the newly formed vessels. Blood 107, 3546-3554

Zacchigna, S., Papa, G., Antonini, A., Novati, F., Moimas, S., Carrer, A., Arsic, N., Zentilin, L., Visintini, V., Pascone, M., Giacca, M. 2005. Improved survival of ischemic cutaneous and musculocutaneous flaps after vascular endothelial growth factor gene transfer using adeno-associated virus vectors. Am. J. Pathol. 167, 981-991

Cereseto, A., Manganaro, L., Gutierrez, M.I., Terreni, M., Fittipaldi, A., Lusic, M., Marcello, A., Giacca, M. 2005. Acetylation of HIV-1 integrase by p300 regulates viral integration. EMBO J. 24, 3070-3081

Galbiati, L., Mendoza-Maldonado, R., Gutierrez, M.I., Giacca, M. 2005. Regulation of E2F-1 after DNA damage by p300-mediated acetylation and ubiquitination. Cell Cycle 4, 930-939

Giacca, M. 2005. HIV-1 Tat, apoptosis and the mitochondria: a tubulin link? Retrovirology 2, 7.

Marchio, S., Alfano, M., Primo, L., Gramaglia, D., Butini, L., Gennero, L., De Vivo, E., Arap, W., Giacca, M., Pasqualini, R., Bussolino, F. 2005. Cell surface-associated Tat modulates HIV-1 infection and spreading through a specific interaction with gp120 viral envelope protein. Blood 105, 2802-2811

Recchia, F.A., Giacca, M. 2005. Targeted uptake-1 carrier to rescue the failing heart. Circ. Res. 97, 847-849

Tasciotti, E., Giacca, M. 2005. Fusion of the human immunodeficiency virus type 1 tat protein transduction domain to thymidine kinase increases bystander effect and induces enhanced tumor killing in vivo. Hum. Gene Ther. 16, 1389-1403

Todorovic, V., Giadrossi, S., Pelizon, C., Mendoza-Maldonado, R., Masai, H., Giacca, M. 2005. Human origins of DNA replication selected from a library of nascent DNA. Mol. Cell. 19, 567-575

Arsic, N., Zacchigna, S., Zentilin, L., Ramirez-Correa, G., Pattarini, L., Salvi, A., Sinagra, G., Giacca, M. 2004. Vascular endothelial growth factor stimulates skeletal muscle regeneration in vivo. Mol Ther 10, 844-854

Di Leva, F., Ferrante, M.I., Demarchi, F., Caravelli, A., Matarazzo, M.R., Giacca, M., D'Urso, M., D'Esposito, M., Franze, A. 2004. Human synaptobrevin-like 1 gene basal transcription is regulated through the interaction of selenocysteine tRNA gene transcription activating factor-zinc finger 143 factors with evolutionary conserved cis-elements. J. Biol. Chem. 279, 7734-7739

Lidonnici, M.R., Rossi, R., Paixao, S., Mendoza-Maldonado, R., Paolinelli, R., Arcangeli, C., Giacca, M., Biamonti, G., Montecucco, A. 2004. Subnuclear distribution of the largest subunit of the human origin recognition complex during the cell cycle. J. Cell Sci. 117, 5221-5231

Marcello, A., Lusic, M., Pegoraro, G., Pellegrini, V., Beltram, F., Giacca, M. 2004. Nuclear organization and the control of HIV-1 transcription. Gene 326, 1-11

Ramirez Correa, G.A., Zacchigna, S., Arsic, N., Zentilin, L., Salvi, A., Sinagra, G., Giacca, M. 2004. Potent inhibition of arterial intimal hyperplasia by TIMP1 gene transfer using AAV vectors. Mol. Ther. 9, 876-884

Zacchigna, S., Zentilin, L., Morini, M., Dell'Eva, R., Noonan, D.M., Albini, A., Giacca, M. 2004. AAV-mediated gene transfer of tissue inhibitor of metalloproteinases-1 inhibits vascular tumor growth and angiogenesis in vivo. Cancer Gene Ther. 11, 73-80

Arsic, N., Zentilin, L., Zacchigna, S., Santoro, D., Stanta, G., Salvi, S., Sinagra, G., Giacca, M. 2003. Induction of functional neovascularization by combined VEGF and angiopoietin-1 gene transfer using AAV vectors. Mol. Ther. 7, 450-459

Ferrari, A., Pellegrini, V., Arcangeli, C., Fittipaldi, A., Giacca, M., Beltram, F. 2003. Caveolae-mediated internalization of extracellular HIV-1 Tat fusion proteins visualized in real time. Mol. Ther. 8, 284-294

Fittipaldi, A., Ferrari, A., Zoppe, M., Arcangeli, C., Pellegrini, V., Beltram, F., Giacca, M. 2003. Cell membrane lipid rafts mediate caveolar endocytosis of HIV-1 Tat fusion proteins. J. Biol. Chem. 278, 34141-34149

Gabellini, D., Colaluca, I.N., Vodermaier, H.C., Biamonti, G., Giacca, M., Falaschi, A., Riva, S., Peverali, F.A. 2003. Early mitotic degradation of the homeoprotein HOXC10 is potentially linked to cell cycle progression. EMBO J. 22, 3715-3724

Galeano, M., Deodato, B., Altavilla, D., Cucinotta, D., Arsic, N., Marini, H., Torre, V., Giacca, M., Squadrito, F. 2003. Adeno-associated viral vector-mediated human vascular endothelial growth factor gene transfer stimulates angiogenesis and wound healing in the genetically diabetic mouse. Diabetologia 46, 546-555

Lusic, M., Marcello, A., Cereseto, A., Giacca, M. 2003. Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter. EMBO J. 22, 6550-6561

Marcello, A., Ferrari, A., Pellegrini, V., Pegoraro, G., Lusic, M., Beltram, F., Giacca, M. 2003. Recruitment of human cyclin T1 to nuclear bodies through direct interaction with the PML protein. EMBO J. 22, 2156-2166

Tasciotti, E., Zoppe, M., Giacca, M. 2003. Transcellular transfer of active HSV-1 thymidine kinase mediated by an 11-amino-acid peptide from HIV-1 Tat. Cancer Gene Ther. 10, 64-74

Deodato, B., Arsic, N., Zentilin, L., Galeano, M., Santoro, D., Torre, V., Altavilla, D., Valdembri, D., Bussolino, F., Squadrito, F., Giacca, M. 2002. Recombinant AAV vector encoding human VEGF165 enhances wound healing. Gene Ther. 9, 777-785

Mendoza-Maldonado, R., Zentilin, L., Fanin, R., Giacca, M. 2002. Purging of chronic myelogenous leukemia cells by retrovirally-expressed anti-bcr/abl ribozymes with specific cellular compartmentalization. Cancer Gene Ther. 9, 71-86

Marcello, A., Cinelli, R.A., Ferrari, A., Signorelli, A., Tyagi, M., Pellegrini, V., Beltram, F., Giacca, M. 2001. Visualization of in vivo direct interaction between HIV-1 Tat and human cyclin T1 in specific subcellular compartments by fluorescence resonance energy transfer. J. Biol. Chem. 276, 39220-39225

Tyagi, M., Rusnati, M., Presta, M., Giacca, M. 2001. Internalization of HIV-1 Tat requires cell surface heparan sulfate proteoglycans. J. Biol. Chem. 276, 3254-3261

Zentilin, L., Marcello, A., Giacca, M. 2001. Involvement of cellular double-strand DNA break-binding proteins in processing of recombinant adeno-associated virus (AAV) genome. J. Virol. 75, 12279-12287

Abdurashidova, G., Deganuto, M., Klima, R., Riva, S., Biamonti, G., Giacca, M., Falaschi, A. 2000. Start sites of bidirectional DNA synthesis at the human lamin B2 origin. Science 287, 2023-2026.

Marcello, A., Massimi, P., Banks, L., Giacca, M. 2000. Adeno-associated virus type 2 Rep protein inhibits human papillomavirus type 16 E2 recruitment of the transcriptional coactivator p300. J. Virol. 74, 9090-9098

Marzio, G., Wagener, C., Gutierrez, M.I., Cartwright, P., Helin, K., Giacca, M. 2000. E2F family members are differentially regulated by reversible acetylation. J. Biol. Chem. 275, 10887-10892

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