Research Groups

Molecular Cardiology

Research Interests and Description
Group Members

Francesco Loffredo

Group Leader

International Centre for Genetic Engineering and Biotechnology
Padriciano 99
34149 Trieste, Italy

E-mail: loffredoicgeb.org
Office tel: +39-040-3757325
Lab tel: +39-040-3757325
Fax: +39-040-226555

Education

Faculty of Medicine, University of Naples “Federico II”, Italy, MD, 2000
Admitted to the Medical Doctors and Surgeons Register, 2001
Second University of Naples, Italy, Fellowship in Cardiology, 2006
Second University of Naples, Italy, PhD, 2011

Career History

Since January 2015, Group Leader of the Molecular Cardiology Laboratory of the ICGEB in Trieste.
2010-2012, PhD student at the University of Naples “Federico II”, Naples.
2007-2014, Research Fellow at Brigham and Women’s Hospital, Harvard Medical School.
2003-2006, Clinical fellow in Cardiology at the Second University of Naples, Naples.
2001-2003, Clinical resident in Internal Medicine at the Second University of Naples, Naples.
1997-2000, Pre-doctoral student and fellow at the Department of Internal Medicine, University of Naples “Federico II”, Naples.
1994-1997, Pre-doctoral student and fellow at the Department of Cellular and Molecular Biology and Pathology, University of Naples “Federico II”, Naples.
1994-2000, MD student at the University of Naples “Federico II”, Naples.

Scientific Activity

Research interest focuses on molecular mechanisms that determine cardiovascular diseases and the development of novel strategies to approach clinical problems, with special attention to identifying circulating factors that can regulate cardiac aging and hypertrophy. F. Loffredo has also been working on engineering proteins to develop targeted therapeutic approach to cardiac regeneration and osteoarthritis. His research activity has been funded through grants from various public and private institutions, including the American Heart Association (AHA), the American Diabetes Association (ADA) and the Italian Society of Cardiology (SIC). He regularly presents his research activity at meetings and seminars worldwide, including articles for lay audience.

Selected publications

Loffredo F on PubMed

Loffredo FS, Nikolova AP, Pancoast JR, Lee RT.   Heart failure with preserved ejection fraction: molecular pathways of the aging myocardium. Circ Res. 2014 Jun 20;115(1):97-107. Review.

Sinha M, Jang YC, Oh J, Khong D, Wu EY, Manohar R, Miller C, Regalado SG, Loffredo FS, Pancoast JR, Hirshman MF, Lebowitz J, Shadrach JL, Cerletti M, Kim MJ, Serwold T, Goodyear LJ, Rosner B, Lee RT, Wagers AJ Restoring Systemic GDF11 Levels Reverses Age-Related Dysfunction in Mouse Skeletal Muscle Science. 2014 May 9;344(6184):649-52.

Katsimpardi L, Litterman NK, Schein PA, Miller CM, Loffredo FS, Wojtkiewicz GR, Chen JW, Lee RT, Wagers AJ, Rubin LL. Vascular and neurogenic rejuvenation of the aging mouse brain by young systemic factors. Science. 2014 May 9;344(6184):630-4

Loffredo FS, Pancoast JR, Cai L, Vannelli T, Dong J, Lee RT, Patwari P Targeted Delivery to Cartilage Is Critical for In Vivo Efficacy of Insulin-like Growth Factor-1 Arthritis Rheumatol.   2014 Jan 27.

Loffredo FS, Pancoast JR, Lee RT. Keep PNUTS in your heart. Circ Res. 2013 Jul 5;113(2):97-9

Loffredo FS, Steinhauser ML, Jay SM, Gannon J, Pancoast JR, Yalamanchi P, Sinha M, Dall'Osso C, Khong D, Shadrach JL, Miller CM, Singer BS, Stewart A, Psychogios N, Gerszten RE, Hartigan AJ, Kim MJ, Serwold T, Wagers AJ, Lee RT Growth differentiation factor 11 is a circulating factor that reverses age-related cardiac hypertrophy. Cell. 2013 May 9;153(4):828-39

Cimmino G, Ragni M, Cirillo P, Petrillo G, Loffredo F, Chiariello M, Gresele P, Falcinelli E, Golino P. C-reactive protein induces expression of matrix metalloproteinase-9: A possible link between inflammation and plaque rupture. Int J Cardiol. 2012 Nov 14.

Gresele P, Falcinelli E, Loffredo F, Cimmino G, Corazzi T, Forte L, Guglielmini G, Momi S, Golino P. Platelets release matrix metalloproteinase-2 in the coronary circulation of patients with acute coronary syndromes: possible role in sustained platelet activation. Eur Heart J. 2011 Feb;32(3):316-25

Forte L, Cimmino G, Loffredo F, De Palma R, Abbate G, Calabrò P, Ingrosso D, Galletti P, Carangio C, Casillo B, Calabrò R, Golino P. C-reactive protein is released in the coronary circulation and causes endothelial dysfunction in patients with acute coronary syndromes. Int J Cardiol. 2011 Oct 6;152(1):7-12

Loffredo FS, Steinhauser ML, Gannon J, Lee RT. Bone-marrow derived cell therapy stimulates endogenous cardiomyocyte progenitors and promotes cardiac repair. Cell Stem Cell. 2011 Apr 8;8(4):389-98.

Loffredo F, Lee RT Therapeutic vasculogenesis: it takes two Circ Res. 2008 Jul 18;103(2):128-30.

Golino P, Loffredo F, Riegler L, Renzullo E, Cocchia R. Novel antithrombotic strategies in cardiovascular diseases. Curr Opin Investig Drugs. 2005 Mar;6(3):298-306.

Golino P, Loffredo F Animal models of platelet-dependent thrombosis. In: Platelets in thrombotic and non thrombotic disorders. Pathophysiology, pharmacology and therapeutics. Paolo Gresele, Clive Page, Valentin Fuster and Jos Vermylen Editors, Cambridge University Press, Cambridge, UK, 2002; pp. 499-514. 

Tufano A, Coppola A, Loffredo F, Garofano T, Celentano A, Di Minno G. Hypercoagulability and atherothrombosis: clinical suggestions and perspectives. Haematologica. 2001 Nov;86(11 Suppl 2):8-11

Golino P, Cirillo P, Calabrò P, Ragni M, D'Andrea D, Avvedimento EV, Vigorito F, Corcione N, Loffredo  F,  Chiariello M.  Expression of  exogenous tissue  factor  pathway inhibitor in  vivo suppresses thrombus formation in injured rabbit carotid arteries. Journal  of  the  American College of Cardiology, 38: 569, 2001.

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AREA Science Park
Padriciano 99
34149 Trieste, ITALY
Tel: +39-040-37571
Fax: +39-040-226555
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