Research Groups

Fabian Feiguin

Neurobiology

Group Leader

Research Interests and Description
Group Members

Fabian Feiguin

International Centre for Genetic Engineering and Biotechnology
Padriciano 99
34149 Trieste, Italy

E-mail: feiguinicgeb.org
Office tel: +39-040-3757201
Lab tel: +39-040-3757202
Office fax: +39-040-226555

Education

Facultad de Medicina, Universidad Nacional de Cordoba, Argentina, MD, 1990
Instituto Mercedes y Martin Ferreyra (CONICET), Cordoba, Argentina, PhD, 1995
Alexander Von Humboldt Foundation Fellowship, EMBL, Heidelberg, Germany, 1996-1998

Career History

January 2007, Group Leader, Neurobiology Laboratory, International Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste, Italy.
2002-2006, Group Leader, Cavalieri Otolenghi Scientific Institute (COSI), University of Torino, Italy.
2000-2002, Associated Researcher, Research Institute of Molecular Pathology (IMP), Vienna, Austria.
1998-2000, Max-Planck Foundation Postdoctoral Fellow, European Molecular Biology Laboratory, Heidelberg, Germany.
1996-1998, Alexander Von Humboldt Foundation Fellowship, EMBL, Heidelberg, Germany.

Teaching Activity

1991-1992, Instructor, Department of Pharmacology, Faculty of Chemical Sciences, National University of Cordoba, Argentina.
1991, Instructor, Center of Electronic Microscopy, Faculty of Medicine, National University of Cordoba, Argentina.

Scientific Activity

Our laboratory is interested in understanding the mechanisms by which neuronal cells define and maintain axons different from dendrites and how these structures are progressively affected by degenerative diseases. For these objectives we utilize Drosophila genetics to re-create human neurodegenerative diseases in flies. The expression of mutant human disease genes or targeting homologous genes in Drosophila confers a unique phenotype to the fly and with these fly models we are identifying the proteins and mechanisms involved in neuronal degeneration.

Selected publications

Feiguin on PubMed

Romano G, Holodkov N, Klima R, Grilli F, Guarnaccia C, Nizzardo M, Rizzo F, Garcia R, Feiguin F. (2018) Downregulation of glutamic acid decarboxylase in Drosophila TDP-43-null brains provokes paralysis by affecting the organization of the neuromuscular synapses.  Sci Rep. doi:10.1038/s41598-018-19802-3.

Appocher C, Mohagheghi F, Cappelli S, Stuani C, Romano M, Feiguin F*, Buratti E*. (2017) Major hnRNP proteins act as general TDP-43 functional modifiers both in Drosophila and human neuronal cells. Nucleic Acids Res. 2017 May 31. doi: 10.1093/nar/gkx477. *co-authors.

Romano, G., Appocher, C., Scorzeto, M., Klima, R., Baralle, F.E., Megighian, A., Feiguin, F. 2015. Glial TDP-43 Regulates Axon Wrapping, GluRIIA Clustering and Fly Motility by Autonomous and Non-Autonomous Mechanisms. Hum Mol Genet ddv330. [Epub ahead of print] PubMed link

Appocher, C., Klima, R., Feiguin, F. 2014. Functional screening in Drosophila reveals the conserved role of REEP1 in promoting stress resistance and preventing the formation of Tau aggregates. Hum Mol Genet ddu393 [Epub ahead of print] PubMed link

Romano, G., Klima, R., Buratti, E., Verstreken, P., Baralle, F.E., Feiguin, F. 2014. Chronological requirements of TDP-43 function in synaptic organization and locomotive control. Neurobiol Dis doi: 10.1016/j.nbd.2014.07.007 [Epub ahead of print] PubMed link

Miskiewicz, K., Jose, L.E., Yeshaw, W.M., Valadas, J.S., Swerts, J., Munck, S., Feiguin, F., Dermaut, B., Verstreken, P. 2014. HDAC6 is a Bruchpilot deacetylase that facilitates neurotransmitter release. Cell Rep Epub PubMed link

Godena, V.K., Romano, G., Romano, M., Appocher, C., Klima, R., Buratti, E., Baralle, F.E., Feiguin, F. 2011. TDP-43 Regulates Drosophila Neuromuscular Junctions Growth by Modulating futsch/MAP-1B Levels and Synaptic Microtubules Organization. PLoS ONE 11, 6 e17808 PubMed link

Feiguin, F., Godena, V.K., Romano, G., D'Ambrogio, A., Klima, R., Baralle, F.E. 2009. Depletion of TDP-43 affects Drosophila motoneurons terminal synapsis and locomotive behaviour. FEBS Lett 583, 1586-1592 PubMed link

Herranz, H., Stamataki, E., Feiguin, F., Milan, M. 2006. Self-refinement of Notch activity through the transmembrane protein Crumbs: modulation of gamma-Secretase activity. EMBO Rep. 7, 297-302

de Anda, F.C., Pollarolo, G., Santos Da Silva, J., Camoletto, P., Feiguin, F*., Dotti, C.G*. 2005. Centrosome localization determines neuronal polarity. Nature 436, 704-708. * co-authors.

Hannus, M., Feiguin, F., Heisenberg, C.P., Eaton, S. 2002. Planar cell polarization requires Widerborst, a B' regulatory subunit of protein phosphatase 2A. Development 129 (14), 3493-3503

Feiguin, F., Hannus, M., Mlodzik, M., Eaton, S. 2001. The ankyrin repeat protein Diego mediates Frizzled-dependent planar polarization. Developmental Cell. 1(1), 93-101.

Paricio, N., Feiguin, F., Boutros, M., Wilson, C., Mlodzik, M. 1999. The Drosophila STE20-like kinase Misshapen is required down stream of Frizzled in planar polarity signaling. EMBO J. 1;18(17), 4669-78.

Feiguin, F., Llamazares, S., and Gonzalez, C. 1998. Methods in Drosophila cell cycle biology. Curr Top Dev Biol. 36, 279-91.

Feiguin, F., Ferreira, A., Kosik, K., and Caceres, A. (1994) Kinesin-mediated organelle translocations revealed by specific cellular manipulations.  J. Cell Biology 127: 1021-1039. 

Cod. Fisc. 90031700322 tl_files/trieste pics/5permille .png

AREA Science Park
Padriciano 99
34149 Trieste, ITALY
Tel: +39-040-37571
Fax: +39-040-226555
icgebicgeb.org
Address book

 

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