Research Groups

Fabian Feiguin

Neurobiology

Group Leader

Research Interests and Description
Group Members

Fabian Feiguin

International Centre for Genetic Engineering and Biotechnology
Padriciano 99
34149 Trieste, Italy

E-mail: feiguinicgeb.org
Office tel: +39-040-3757201
Lab tel: +39-040-3757202
Office fax: +39-040-226555

Education

Facultad de Medicina, Universidad Nacional de Cordoba, Argentina, MD, 1990
Instituto Mercedes y Martin Ferreyra (CONICET), Cordoba Argentina, PhD, 1995

Career History

January 2006, Group Leader, Neurobiology Laboratory, International Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste, Italy.
2002-2005, Junior Group Leader, Cavalieri Otolenghi Scientific Institute (COSI), University of Torino, Italy.
2000-2002, Senior Postdoc, Research Institute of Molecular Pathology (IMP), Vienna, Austria.
1998-2000, Max-Planck Foundation postdoctoral fellow, European Molecular Biology Laboratory, Heidelberg, Germany.
1996-1998, Alexander Von Humboldt Foundation Fellowship, EMBL, Heidelberg, Germany.
1993, Visiting Fellow, Brigham and Women’s Hospital, Center of Neurological Diseases, Harvard Medical School, Boston, USA.

Teaching Activity

1991-1992, Instructor, Department of Pharmacology, Faculty of Chemical Sciences, National University of Cordoba, Argentina.
1991, Instructor, Center of Electronic Microscopy, Faculty of Medicine, National University of Cordoba, Argentina.

Scientific Activity

Our laboratory in interested in understanding the mechanisms by which neuronal cells define and maintain axons different from dendrites and how these structures are progressively affected by degenerative diseases. For that we are using genetic, biochemical and histological approaches to identify the machinery involved in the formation of axons and dendrites in Drosophila sensitive neurons.   We also utilize these tools to re-create human neurodegenerative diseases in flies. The expression of mutant human disease genes or targeting homologous genes in Drosophila confers a unique phenotype to the fly and with these fly models we are identifying the genes and mechanisms involved in progression or suppression of neuronal degeneration.

Selected publications

Godena, V.K., Romano, G., Romano, M., Appocher, C., Klima, R., Buratti, E., Baralle, F.E., Feiguin, F. 2011. TDP-43 Regulates Drosophila Neuromuscular Junctions Growth by Modulating futsch/MAP-1B Levels and Synaptic Microtubules Organization. PLoS ONE 11, 6 e17808 PubMed link

Feiguin, F., Godena, V.K., Romano, G., D'Ambrogio, A., Klima, R., Baralle, F.E. 2009. Depletion of TDP-43 affects Drosophila motoneurons terminal synapsis and locomotive behaviour. FEBS Lett 583, 1586-1592 PubMed link

Llamusi, B., Bargiela, A., Fernandez-Costa, J.M., Garcia-Lopez, A., Klima, R., Feiguin, F., Artero, R. 2013. Muscleblind, BSF and TBPH are mislocalized in the muscle sarcomere of a Drosophila myotonic dystrophy model. Dis Model Mech 6, 184-196

Michaki, V., Guix, F.X., Vennekens, K., Munck, S., Dingwall, C., Davis, J.B., Townsend, D.M., Tew, K.D., Feiguin, F., de Strooper, B., Dotti, C.G., Wahle, T. 2012. Downregulation of the ATP-binding cassette transporter 2 (Abca2) reduces Amyloid-β production by altering Nicastrin maturation and intracellular localization. J Biol Chem 287, 1100-1111 

Nesic, I., Guix, F., Vennekens, K., Michaki, V., Van Veldhoven, P.P., Feiguin, F., de Strooper, B., Dotti, C.G., Wahle, T. 2012. Alterations in Phosphatidylethanolamine levels affect the generation of Aβ. Aging Cell 11, 63-72

Romano, M., Feiguin, F., Buratti, E. 2012. Drosophila Answers to TDP-43 Proteinopathies. J Amino Acids 2012356081

Marcucci, R., Romano, M., Feiguin, F., O'Connell, M.A., Baralle, F.E. 2009. Dissecting the splicing mechanism of the Drosophila editing enzyme; dADAR. Nucleic Acids Res 37, 1663-1671 PubMed link

Herranz, H., Stamataki, E., Feiguin, F., Milan, M. 2006. Self-refinement of Notch activity through the transmembrane protein Crumbs: modulation of gamma-Secretase activity. EMBO Rep. 7, 297-302 PubMed link

Calderon de Anda, F., Pollarolo, G., Santos Da Silva, J., Camoletto, P., Feiguin, F., Dotti, C.G. 2005. Centrosome localization determines neuronal polarity. Nature 436, 704-708 PubMed link

Herranz, H., Stamataki, E., Feiguin, F., Milan, M. 2006. Self-refinement of Notch activity through the transmembrane protein Crumbs: modulation of gamma-Secretase activity. EMBO Rep. 7, 297-302

de Anda, F.C., Pollarolo, G., Santos Da Silva, J., Camoletto, P., Feiguin, F., Dotti, C.G. 2005. Centrosome localization determines neuronal polarity. Nature 436, 704-708

Hannus, M., Feiguin, F., Heisenberg, C.P., Eaton, S. 2002. Planar cell polarization requires Widerborst, a B' regulatory subunit of protein phosphatase 2A. Development 129 (14), 3493-3503

Feiguin, F., Hannus, M., Mlodzik, M., Eaton, S. 2001. The ankyrin repeat protein Diego mediates Frizzled-dependent planar polarization. Developmental Cell. 1(1), 93-101.

Paricio, N., Feiguin, F., Boutros, M., Wilson, C., Mlodzik, M. 1999. The Drosophila STE20-like kinase Misshapen is required down stream of Frizzled in planar polarity signaling. EMBO J. 1;18(17), 4669-78.

Feiguin, F., Llamazares, S., and Gonzalez, C. 1998. Methods in Drosophila cell cycle biology. Curr Top Dev Biol. 36, 279-91.

Cod. Fisc. 90031700322 tl_files/trieste pics/5permille .png

AREA Science Park
Padriciano 99
34149 Trieste, ITALY
Tel: +39-040-37571
Fax: +39-040-226555
icgebicgeb.org
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