Research Groups

Dinkar Sahal

Malaria Drug Discovery

Group Leader

Research Interests and Description

Dinkar Sahal

International Centre for Genetic Engineering and Biotechnology
Aruna Asaf Ali Marg
110 067 New Delhi, India

E-mail: dinkaricgeb.res.in
Office tel: +91-11-26742357
Office fax: +91-11-26742316

Education

All India Institute of Medical Sciences, New Delhi, India, PhD, 1984
MS University, Baroda, India, MSc, 1977

Career History

Since 1998, Staff Research Scientist, Malaria Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi, India
1992-1998, Senior Research Scientist, Recombinant Gene Products, ICGEB, New Delhi
1986-1988, Research Fellow, Department of Molecular Genetics, Beckman Research Institute of the City of Hope, Duarte, California
1984-1986: Research Associate, Molecular Biophysics Unit, Indian Institute of Science, Bangalore 

Scientific Activity

Antibiotics and antimalarials; de novo design, chemical synthesis and solution and solid state structures of helix turn helix and helix-beta hairpin motifs; design synthesis and biological action of highly evolved antimicrobial peptides, structure-function mechanisms of action and specificity; peptide-peptide and peptide-non peptide antibiotic combinations.

Selected publications

Kaushik, N., Bagavan, A., Rahuman, A. A., Zahir, A. A., Kamaraj, C., Elango, G., Jayaseelan, C., Kirthi, A. V., Santhoshkumar, T., Marimuthu, S., Rajakumar, G., Tiwari, S. K., Sahal, D., 2015. Evaluation of antiplasmodial activity of medicinal plants from North Indian Buchpora and South Indian Eastern Ghats. Malaria Journal (In Press)

Singh, N., Kaushik, N.K., Mohanakrishnan, D., Tiwari, S. K., Sahal, D. 2015. Antiplasmodial Activity of Medicinal Plants from Chhotanagpur Plateau, Jharkhand, India. Journal of Ethnopharmacology. 165: 152–162. PubMed link

Suryanarayanan, T. S. , Gopalan, V., Sahal, D. and Sanyal, K. 2015. Establishing a national fungal genetic resource to enhance the bioeconomy. Current Science. 109: 1033-1037.

Sabareesh, V., Sahal, D. 2015. Explorations into conformationally distinct isomeric peptides of opposite directionalities by high resolution electrospray collision induced dissociation tandem mass spectrometry. International Journal of MassSpectrometry. 391: 31– 40.

Vijay Kumar and Dinkar Sahal. 2014. Genetic Engineering, Ullmann’s Encyclopedia of Industrial Chemistry

Veerabadhran M, Manivel N, Mohanakrishnan D, Sahal D, Muthuraman S. 2014. Antiplasmodial activity of extracts of twenty five    cyanobacterial species from coastal regions of Tamil Nadu. Pharm Biology. 52: 1291-301. PubMed link

Sharma, N., Mohanakrishnan, D., Sharma, U.K., Kumar, R.,  Richa, Sinha, A. K., Sahal, D. 2014. Design, economical synthesis and evaluation of antiplasmodial properties of natural vanillin-based allylated chalcones and their marked synergistic effect with artemisinin against chloroquine resistant strains of Plasmodium falciparum. Eur J Med Chem. 79: 350-68. PubMed link

Kaushik, N. K., Murali, T. S., Sahal, D., Suryanarayanan, T.S. 2014. A search for antiplasmodial metabolites among fungal endophytes of terrestrial and marine plants of southern India. Acta Parasitol. 59: 745-57. PubMed link

Kumari, P., Sahal, D., Chauhan, V.S. 2014. Dendrimeric Template of Plasmodium falciparum Histidine Rich Protein II repeat motifs bearing Asp-Asn mutation exhibits heme binding and β-hematin formation. PLoS One. 9: e112087. PubMed link

Mishra, A., Kaushik, N.K., Sardara, M., Sahal, D. 2013. Evaluation of antiplasmodial activity of green synthesized silver Nanoparticles. Colloids and Surfaces B: Biointerfaces 111:713– 718.

Dinkar Sahal. 2013. The Joy of Imprinting. Cutting Edge, August, 7-16.

ICGEB New Delhi

ICGEB Campus
Aruna Asaf Ali Marg
110 067 New Delhi
INDIA
Tel: +91-11-26741358
Fax: +91-11-26742316
icgebicgeb.res.in

 

 

 tl_files/iTunes_Badge_Color_master_10251024.png

tl_files/FB.png tl_files/Twitter_logo_blue-1def.png tl_files/rss.png
tl_files/LinkedIn-InBug-2CRev2.png tl_files/YouTube.png