Research Groups

Dhiraj Kumar

Cellular Immunology

Group Leader

Research Interests and Description

Dhiraj Kumar

ICGEB Laboratories
ICGEB Campus
Aruna Asaf Ali Marg
110 067 New Delhi, INDIA

E-mail: dhirajicgeb.res.in
Office tel: +91-11-26741358, 61, 2357, 2360 ext. 113
Office fax: +91-11-26715114

Education

International Centre for Genetic Engineering and Biotechnology ICGEB, New Delhi, India, PhD, 2007
INdian Agricultural Research Institute, New Delhi, India, MSc, 2002

Career History

Since 2010, Staff Research Scientist, Immunology Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi, India.
2007-2010, Research Scientist, Immunology Group, ICGEB New Delhi, India
2002-2007, Graduate Student, Immunology Group, ICGEB New Delhi, India

Scientific Activity

Understanding Host-Pathogen Interactions in case of Mycobacterium tuberculosis infection using high throughput experimentation and integrative (global) analytical approaches, dynamic modeling of signaling events in biological systems and design principles of biological networks.

Selected Publications

Kumar, D., Nath, L., Kamal, M. A., Varshney, A., Jain, A., Singh, S., Rao, K.V. 2010. Genome-wide analysis of the host intracellular network that regulates survival of Mycobacterium tuberculosis. Cell 140, 731-743

Jayaswal, S., Kamal, M.A., Dua, R., Gupta, S., Majumdar, T., Das, G., Kumar, D., Rao, K.V.S. 2010. Identification of host-dependent survival factors for intracellular Mycobacterium tuberculosis through an siRNA screen. PLoS Pathogen 6 [e1000839]

Chaudhri, V.K., Kumar, D., Misra, M., Dua, R., Rao, K.V.S. 2010. Integration of a phosphatase cascade with the mitogen-activated protein kinase pathway provides for a novel signal processing function. J Biol Chem 285, 1296-1310

Basu, S.K., Kumar, D., Ganguly, N., Rao, K.V.S., Sharma, P. 2009. Mycobacterium tuberculosis secreted antigen (MTSA-10) inhibits macrophage response to lipopolysaccharide by redox regulation of phosphatases. Indian J Exp Biol 47, 505-519

Kumar, D., Dua, R., Srikanth, R., Jayaswal, S., Siddiqui, Z., Rao, K.V.S. 2008. Cellular phosphatases facilitate combinatorial processing of receptor-activated signals. BMC Res Notes 1, 81

Kumar, D., Srikanth, R., Ahlfors, H., Lahesmaa, R., Rao, K.V.S. 2007. Capturing cell-fate decisions from the molecular signatures of a receptor-dependent signaling response. Mol Syst Biol 3, 150

Basu, S.K., Kumar, D., Singh, D. K., Ganguly, N., Siddiqui, Z., Rao, K.V., Sharma, P. 2006. Mycobacterium tuberculosis secreted antigen (MTSA-10) modulates macrophage function by redox regulation of phosphatases. Febs J 273, 5517-5534

Singh, D.K., Kumar, D., Siddiqui, Z., Basu, S.K., Kumar, V., Rao, K.V.S. 2005. The strength of receptor signaling is centrally controlled through a cooperative loop between Ca2+ and an oxidant signal. Cell 121, 281-293

ICGEB New Delhi

ICGEB Campus
Aruna Asaf Ali Marg
110 067 New Delhi
INDIA
Tel: +91-11-26741358/1007
Fax: +91-11-26742316
icgebicgeb.res.in

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