Research Groups

Dhiraj Kumar

Cellular Immunology

Group Leader

Research Interests and Description

Dhiraj Kumar

ICGEB Laboratories
ICGEB Campus
Aruna Asaf Ali Marg
110 067 New Delhi, INDIA

E-mail: dhirajicgeb.res.in
Office tel: +91-11-26741358, 61, 2357, 2360 ext. 113
Office fax: +91-11-26715114

Education

International Centre for Genetic Engineering and Biotechnology ICGEB, New Delhi, India, PhD, 2007
INdian Agricultural Research Institute, New Delhi, India, MSc, 2002

Career History

Since 2018, Wellcome-DBT India Alliance Senior Fellow
Since 2016, Group Leader, Cellular Immunology Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi, India
2010-2015, Staff Research Scientist, Immunology Group, ICGEB New Delhi
2007-2010, Research Scientist, Immunology Group, ICGEB New Delhi
2002-2007, Graduate Student, Immunology Group, ICGEB New Delhi

Scientific Activity

Understanding Host-Pathogen Interactions in case of Mycobacterium tuberculosis infection using high throughput experimentation and integrative (global) analytical approaches, dynamic modeling of signaling events in biological systems and design principles of biological networks.

Selected Publications

Vashi N, Andrabi SB, Ghanwat S, Suar M, Kumar D: Ca2+-dependent Focal Exocytosis of Golgi-derived Vesicles Helps Phagocytic Uptake in Macrophages. J Biol Chem 2017, 292:5144-5165.

Kalam H, Fontana MF, Kumar D: Alternate splicing of transcripts shape macrophage response to Mycobacterium tuberculosis infection. PLoS Pathog 2017, 13:e1006236.

Matta SKK, D.: Hypoxia and classical activation limits Mycobacterium tuberculosis survival by Akt-dependent glycolytic shift in macrophages. Cell Death Discovery 2016, 2.

Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, et al: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy 2016, 12:1-222.

Chandra PR, RS; Verma, G; Bhavesh NS and Kumar D. : Targeting Drug-Sensitive and-Resistant Strains of Mycobacterium tuberculosis by Inhibition of Src Family Kinases Lowers Disease Burden and Pathology. mSphere 2016, 1:e00043-00015.

Chandra P, Kumar D: Selective autophagy gets more selective: Uncoupling of autophagy flux and xenophagy flux in Mycobacterium tuberculosis-infected macrophages. Autophagy 2016, 12:608-609.

Samdani P, Singhal M, Sinha N, Tripathi P, Sharma S, Tikoo K, Rao KV, Kumar D: A Comprehensive Inter-Tissue Crosstalk Analysis Underlying Progression and Control of Obesity and Diabetes. Sci Rep 2015, 5:12340.

Matta SK, Kumar D: AKT mediated glycolytic shift regulates autophagy in classically activated macrophages. Int J Biochem Cell Biol 2015, 66:121-133.

Chandra P, Ghanwat S, Matta SK, Yadav SS, Mehta M, Siddiqui Z, Singh A, Kumar D: Mycobacterium tuberculosis Inhibits RAB7 Recruitment to Selectively Modulate Autophagy Flux in Macrophages. Sci Rep 2015, 5:16320.

Karim AF, Chandra P, Chopra A, Siddiqui Z, Bhaskar A, Singh A, Kumar D: Express path analysis identifies a tyrosine kinase Src-centric network regulating divergent host responses to Mycobacterium tuberculosis infection. J Biol Chem 2011, 286:40307-40319.

Chatterjee S, Kumar D: Unraveling the design principle for motif organization in signaling networks. PLoS One 2011, 6:e28606.

Kumar D, Nath L, Kamal MA, Varshney A, Jain A, Singh S, Rao KV: Genome-wide analysis of the host intracellular network that regulates survival of Mycobacterium tuberculosis. Cell 2010, 140:731-743.

Jayaswal S, Kamal MA, Dua R, Gupta S, Majumdar T, Das G, Kumar D, Rao KV: Identification of host-dependent survival factors for intracellular Mycobacterium tuberculosis through an siRNA screen. PLoS Pathog 2010, 6:e1000839.

Kumar D, Srikanth R, Ahlfors H, Lahesmaa R, Rao KV: Capturing cell-fate decisions from the molecular signatures of a receptor-dependent signaling response. Mol Syst Biol 2007, 3:150.

Singh DK, Kumar D, Siddiqui Z, Basu SK, Kumar V, Rao KV: The strength of receptor signaling is centrally controlled through a cooperative loop between Ca2+ and an oxidant signal. Cell 2005, 121:281-293.

ICGEB New Delhi

ICGEB Campus
Aruna Asaf Ali Marg
110 067 New Delhi
INDIA
Tel: +91-11-26741358/1007
Fax: +91-11-26742316
icgebicgeb.res.in

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