Research Groups

Cardiovascular Biology

Research Interests and Description

Group Leader: Serena Zacchigna, MD, PhD (on Sp. L)

Group Members

Research Interests

Cell-cell interactions and cross-talk in angiogenesis, cancer and cardiac disease

Description of Research

Research projects aim to identify the mechanisms by which the various cell types composing the cardiovascular system interact and communicate during development and disease. Particular interest is dedicated to the cross-talk between endothelial cells and cardiomyocytes. Thanks to established collaborations with multiple clinical units, the laboratory is particularly dedicated to the use of cellular and animal models of human diseases, as well as of viral and non-viral gene transfer approaches, to eventually develop novel therapeutic approaches for tissue revascularization and cancer treatment.

A second interest of the Group is in the field of laser therapy and optogenetics. In particular, we are investigating the mechanisms by which laser light interacts with biological tissues and exploiting light to control gene expression.

Recent Publications

Zacchigna, S., Martinelli, V., Moimas, S., Colliva, A., Anzini, M., Nordio, A., Costa, A., Pierro, C., Colussi, G., Rehman, M., Vodret, S., Zentilin, L., Gutierrez, M., Dirkx, E., Long, C., Sinagra, G., Klatzmann, D., Giacca, M. Paracrine effect of regulatory T cells promotes cardiomyocyte proliferation during pregnancy and after myocardial infarction. Nature Commun 2018 In press

Bortolotti, F., Ruozi, G., Falcione, A., Doimo, S., Dal Ferro, M., Lesizza, P., Zentilin, L., Banks, L., Zacchigna, S., Giacca, M. In Vivo Functional Selection Identifies Cardiotrophin-1 as a Cardiac Engraftment Factor for Mesenchymal Stromal Cells. Circulation 2017 136, 1509-1524 PubMed link

Ottaviani, G., Martinelli, V., Rupel, K., Caronni, N., Naseem, A., Zandonà, L., Perinetti, G., Gobbo, M., Di Lenarda, R., Bussani, R., Benvenuti, F., Giacca, M., Biasotto, M., Zacchigna, S. Laser Therapy Inhibits Tumor Growth in Mice by Promoting Immune Surveillance and Vessel Normalization. EBioMedicine.  2016, 11, 165-172 PubMed link

Bortolotti, F., Ukovich, L., Razban, V., Martinelli, V., Ruozi, G., Pelos, B., Dore F., Giacca, M., Zacchigna, S. In vivo therapeutic potential of mesenchymal stromal cells depends on source and isolation procedure. Stem Cell Reports, 2015 Mar 10;4(3):332-9 PubMed link

Zacchigna, S., Giacca, M. Extra- and intracellular factors regulating cardiomyocyte proliferation in postnatal life. Cardiovasc Res. 2014, 102, 312-20 PubMed link

Zacchigna S, Zentilin L, Giacca M. Adeno-associated virus vectors as therapeutic and investigational tools in the cardiovascular system. Circ Res 2014,114, 1827-46 PubMed link

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AREA Science Park
Padriciano 99
34149 Trieste, ITALY
Tel: +39-040-37571
Fax: +39-040-226555
icgebicgeb.org
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