Research Groups

Arulandu

Membrane Protein Biology

Group Leader

Research Interests and Description

Arockiasamy Arulandu

International Centre for Genetic Engineering and Biotechnology
Aruna Asaf Ali Marg
110 067 New Delhi, India

E-mail: samicgeb.res.in

Education

Madurai Kamarai University, Madurai, India, MSc, 1993
Madurai Kamarai University, Madurai, India, PhD, 2000

Career History

Since 2007, Staff Research Scientist, Structural and Computational Biology Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi, India
2003-2006, Assistant Research Scientist, Texas A&M University, Texas, USA
2001-2003, Post-doctoral Research Associate, Texas A&M University
2000-2001, Post-doctoral Research Associate, University of Illinois at Chicago, USA
1991-2000, Junior and Senior Research Fellow (CSIR-NET), Madurai Kamaraj University, Tamil Nadu, India
1993-1994, Junior Research Fellow, Anna University, Chennai, Tamil Nadu, India

Scientific Activity

My lab is interested in understanding the mechanistic details of ion movement and protein translocation across inner membranes of bacterial pathogens, primarily Mycobacterium tuberculosis. We use the tools of biochemistry, biophysics and structural molecular biology to address important questions concerning the overall architecture and molecular determinants behind substrate selection and transport/secretion. Since many (60%) of the currently available drugs in the market target membrane proteins, basic structure-function understanding of these proteins and their complexes could provide valuable contributions to improve human health.

Selected publications

Maindola, P., Raina, R., Goyal, P., Atmakuri, K., Ojha, A., Gupta, S., Christie, P.J., Iyer, L.M., Aravind, L., Arockiasamy, A. 2014. Multiple enzymatic activities of ParB/Srx superfamily mediate sexual conflict among conjugative plasmids. Nature Comm 5, Art. no. 5322 doi:10.1038/ncomms6322 

Xu, M., Arockiasamy, A., Struck, D.K., Swanson, S., Sacchettini, J.C., Young, R. 2005. Disulfide isomerization after membrane release of its SAR domain activates P1 lysozyme. Science 307, 113-117

Arockiasamy, A., Murthy, G.S., Rukmini, M.R., Sundara Baalaji, N., Katpally, U.C., Krishnaswamy, S. 2004. Conformational epitope mapping of OmpC, a major cell surface antigen from S. typhi. J. Struct. Biol. 148, 22-33

Arockiasamy, A..Kumar, P.D., Sundara Baalaji, N., Rukmini, M.R., Krishnaswamy, S. 2004. Folding and structural stability of OmpC from Salmonella typhi: Role of LPS and environment. Curr. Sci. 87, 197-202

Sharma, V., Arockiasamy* A., Ronning, D.R., Savva, C.G., Holzenburg, A., Braunstein, M., Jacobs, Jr., W. R., Sacchettini. J.C. 2003. Crystal structure of M. tuberculosis SecA, a preprotein translocating ATPase. Proc. Natl. Acad. Sci. USA 100, 2243-2248 [*co- first author]

Sujatha, S., Arockiasamy, A., Krishnaswamy, S.,Usha, R. 2001. Molecular modelling of epitope presentation using membrane protein OmpC. Indian J. Biochem. Biophys. 38, 294-297

Arockiasamy, A., Krishnaswamy, S. 2000. Purification of integral outermembrane protein OmpC, a surface antigen from Salmonella typhi for structure-function studies; a method applicable to Enterobacterial major outer membrane protein. Anal. Biochem. 283, 64-70

Arockiasamy, S., Krishnaswamy, S. 2000. Homology model of major surface antigen OmpC from Salmonella typhi and its functional implications. J. Biomol. Struct. Dyn. 18, 261-271

Gnanasekaran, T.V., Suraj Peri, A. Arockiasamy, A.,Krishnaswamy, S. 2000. Profiles from structure based sequence alignment of porins can identify b-stranded membrane proteins. Bioinformatics 16, 839-842

Arockiasamy, A.,Krishnaswamy,S. 1999. Crystallization of the immunodominant outer membrane protein OmpC; the first protein crystals from Salmonella typhi, a human pathogen. FEBS Lett. 453, 380-382

Arockiasamy, A.,Krishnaswamy, S. 1995. Prediction of B-Cell epitopes for Salmonella typhi OmpC. J. Biosci. 20, 235-243

ICGEB New Delhi

ICGEB Campus
Aruna Asaf Ali Marg
110 067 New Delhi
INDIA
Tel: +91-11-26741358/1007
Fax: +91-11-26742316
icgebicgeb.res.in

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