Research Groups

Anmol Chandele

ICGEB-Emory Vaccine Program

Group Leader

Research Interests and Description

Anmol Chandele

International Centre for Genetic Engineering and Biotechnology
Aruna Asaf Ali Marg
110 067 New Delhi, India

Lab tel: +91-11-26741358 ext. 180 or 181


National Center for Cell Science, India, PhD
Yale University, Postdoc

Career History

2012- Assistant Professor, ICGEB-EMORY Vaccine Program, ICGEB New Delhi, India
2009: Research Scientist, EMORY Vaccine Centre

Scientific Activity

By training young scientists in setting up state of the art immunology tools and techniques (eg high throughput human monoclonal antibody production, single cell sorting, MHC tetramer technology, T cell epitope mapping, single cell intracellular cytokine assays, and somatic hypermutation analysis) in the lab at ICGEB, the goals of the ongoing research are to gain an in-depth understanding of human immunity dengue and chikungunya virus infections.

1. Using systems biology to define the molecular signatures of innate and adaptive immune responses during dengue and chikungunya infection.

2. To determine whether IgG Fc glycan composition is a determinant of antibody functionality and its impact on pathogenesis of disease.

3. To characterize the human B cell response during dengue and chikungunya infection – their functionality, specificity, isotype usage and affinity maturation.

4. To phenotypically and functionally characterize CD4 and CD8 T cell responses in dengue and chikungunya patients.

5. To generate human monoclonal antibodies that may provide novel avenues towards dengue and chikungunya therapeutics. 

Selected publications

Anmol Chandele:

Chandele, A., Sewatanon, J., Gunisetty, S., Singla, M., Onlamoon, N., Akondy, R.S., Kissick, H.T., Nayak, K., Reddy, E.S., Kalam, H., Kumar, D., Verma, A., Panda, H., Wang, S., Angkasekwinai, N., Pattanapanyasat, K., Chokephaibulkit, K., Medigeshi, G.R., Lodha, R., Kabra, S., Ahmed, R., Murali-Krishna, K. 2016. Characterization of Human CD8 T Cell Responses in Dengue Virus-Infected Patients from India. J Virol 90, 11259-11278 PubMed link

Carpenter, C., Sidney, J., Kolla, R., Nayak, K., Tomiyama, H., Tomiyama, C., Padilla, O.A., Rozot, V., Ahamed, S.F., Ponte, C., Rolla, V., Antas, P.R., Chandele, A., Kenneth, J., Laxmi, S., Makgotlho, E., Vanini, V., Ippolito, G., Kazanova, A.S., Panteleev, A.V., Hanekom, W., Mayanja-Kizza, H., Lewinsohn, D., Saito, M., McElrath, M.J., Boom, W.H., Goletti, D., Gilman, R., Lyadova, I.V., Scriba, T.J., Kallas, E.G., Murali-Krishna, K., Sette, A., Lindestam Arlehamn, C.S. 2015. A side-by-side comparison of T cell reactivity to fifty-nine Mycobacterium tuberculosis antigens in diverse populations from five continents. Tuberculosis (Edinb). 95, 713-21. PubMed link

Nayak, K., Jing, L., Russell, R.M., Davies, D.H., Hermanson, G., Molina, D.M., Liang, X., Sherman, D.R., Kwok, W.W., Yang, J., Kenneth, J., Ahamed, S.F., Chandele, A., Murali-Krishna, K., Koelle, D.M. 2015. Identification of novel Mycobacterium tuberculosis CD4 T-cell antigens via high throughput proteome screening. Tuberculosis (Edinb) 95, 275-87 PubMed link

Kulkarni RR, Rasheed MA, Bhaumik SK, Ranjan P, Cao W, Davis C, Marisetti K, Thomas S, Gangappa S, Sambhara S, Murali-Krishna K. 2014. Activation of the RIG-I pathway during influenza vaccination enhances the germinal center reaction, promotes T follicular helper cell induction, and provides a dose-sparing effect and protective immunity. J Virol. 88:13990-4001 PubMed Link

Wrammert, J., Murali-Krishna, K. 2014. Cellular screens to interrogate the human T and B cell repertoires and design better vaccines. Vaccine design 

Wrammert J, Onlamoon N, Akondy RS, Perng GC, Polsrila K, Chandele A, Kwissa M, Pulendran B, Wilson PC, Wittawatmongkol O, Yoksan S, Angkasekwinai N, Pattanapanyasat K, Chokephaibulkit K, Ahmed R. 2012. Rapid and massive virus-specific plasmablast responses during acute dengue virus infection in humans. J Virol. 86: 2911-2918 PubMed link

Marshall, H.D., Chandele, A., Jung, Y.W., Meng, H., Poholek, A.C., Parish, I.A., Rutishauser, R., Cui, W., Kleinstein, S.H., Craft, J., Kaech, S.M. 2011.Differential expression of Ly6C and T-bet distinguish effector and memory Th1 CD4(+) cell properties during viral infection. Immunity 35, 633-646 PubMed link

Chandele, A., Mukerjee, P., Das, G., Ahmed, R., Chauhan, V.S. 2011. Phenotypic and functional profiling of malaria-induced CD8 and CD4 T cells during blood-stage infection with Plasmodium yoelii. Immunology. 2011 132, 273-286 PubMed link

ICGEB New Delhi

ICGEB Campus
Aruna Asaf Ali Marg
110 067 New Delhi
Tel: +91-11-26741358/1007
Fax: +91-11-26742316




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