Archive of Kirill's P450 Café - 2008

by Kirill Degtyarenko

Last modified: Fri Nov 28 14:08:49 GMT 2008

21 November 2008.

• Rentmeister, A., Arnold, F.H. and Fasan, R. (2008) Chemo-enzymatic fluorination of unactivated organic compounds. Nature Chem. Biol., in press.

14 November 2008.

• Fasan, R., Meharenna, Y.T., Snow, C.D., Poulos, T.L. and Arnold, F.H. (2008) Evolutionary history of a specialized P450 propane monooxygenase. J. Mol. Biol. 383, 1069-1080.

7 November 2008.

• Hlavica, P. (2008) Assembly of non-natural electron transfer conduits in the cytochrome P450 system: A critical assessment and update of artificial redox constructs amenable to exploitation in biotechnological areas. Biotechnol. Adv., in press.

17 October 2008.

• Huttunen, K.M., Mähönen, N., Raunio, H. and Rautio, J. (2008) Cytochrome P450-activated prodrugs: targeted drug delivery. Curr. Med. Chem. 15, 2346-2365.

10 October 2008.

• Wallrapp, F., Masone, D. and Guallar, V. (2008) Electron transfer in the P450cam/PDX complex. The QM/MM e-pathway. J. Phys. Chem. A, in press.

3 October 2008.

• Virus, C. and Bernhardt, R. (2008) Molecular evolution of a steroid hydroxylating cytochrome P450 using a versatile steroid detection system for screening. Lipids, in press.

26 September 2008.

• Porubsky, P.R., Meneely, K.M. and Scott, E.E. (2008) Structures of human cytochrome P450 2E1: insights into the binding of inhibitors and both small molecular weight and fatty acid substrates. J. Biol. Chem. 283, 33698-33707.

19 September 2008.

• Li, L., Chang, Z., Pan, Z., Fu, Z.Q. and Wang, X. (2008) Modes of heme binding and substrate access for cytochrome P450 CYP74A revealed by crystal structures of allene oxide synthase. Proc. Natl. Acad. Sci. USA 105, 13883-13888.

12 September 2008.

• Kartha, J.S., Skordos, K.W., Sun, H., Hall, C., Easterwood, L.M., Reilly, C.A., Johnson, E.F. and Yost, G.S. (2008) Single mutations change CYP2F3 from a dehydrogenase of 3-methylindole to an oxygenase. Biochemistry 47, 9756-9770.

5 September 2008.

• Bell, S.G., Xu, F., Forward, I., Bartlam, M., Rao, Z. and Wong, L.-L. (2008) Crystal structure of CYP199A2, a para-substituted benzoic acid oxidizing cytochrome P450 from Rhodopseudomonas palustris. J. Mol. Biol. 383, 561-574.

29 August 2008.

• Silva, D.C., DeFreitas-Silva, G., Nascimento, E.D., Rebouças, J.S., Barbeira, P.J.S., de Carvalho, M.E.M. and Idemori, Y.M. (2008) Spectral, electrochemical, and catalytic properties of a homologous series of manganese porphyrins as cytochrome P450 model: The effect of the degree of β-bromination. J. Inorg. Biochem. 102, 1932-1941.

15 August 2008.

• Woithe, K., Geib, N., Meyer, O., Wörtz, T., Zerbe, K. and Robinson, J.A. (2008) Exploring the substrate specificity of OxyB, a phenol coupling P450 enzyme involved in vancomycin biosynthesis. Org. Biomol. Chem. 6, 2861-2867.

8 August 2008.

• Kawahigashi, H., Hirose, S., Ohkawa, H. and Ohkawa, Y. (2008) Transgenic rice plants expressing human P450 genes involved in xenobiotic metabolism for phytoremediation. J. Mol. Microbiol. Biotechnol. 15, 212-219.

1 August 2008.

• Miksys, S. and Tyndale, R.F. (2008) Brain drug-metabolizing cytochrome P450 enzymes are active in vivo, demonstrated by mechanism-based enzyme inhibition. Neuropsychopharmacology, in press.

25 July 2008.

• McLean, K.J. and Munro, A.W. (2008) Structural biology and biochemistry of cytochrome P450 systems in Mycobacterium tuberculosis. Drug Metab Rev. 40, 427-446.

18 July 2008.

• Hao, M., Zhao, Y., Chen, P., Huang, H., Liu, H., Jiang, H., Zhang, R. and Wang, H. (2008) Structure-activity relationship and substrate-dependent phenomena in effects of ginsenosides on activities of drug-metabolizing P450 enzymes. PLoS ONE 3, e2697.

11 July 2008.

• Chang, Z., Li, L., Pan, Z. and Wang, X. (2008) Crystallization and preliminary X-ray analysis of allene oxide synthase, cytochrome P450 CYP74A2, from Parthenium argentatum. Acta Crystallogr. F64, 668-670.

4 July 2008.

• Evans, J.P., Niemevz, F., Buldain, G. and Ortiz de Montellano, P.R. (2008) Isoporphyrin intermediate in heme oxygenase catalysis: oxidation of α-meso-phenylheme. J. Biol. Chem. 283, 19530-19539.

27 June 2008.

• Ouyang, B., Pochapsky, S.S., Dang, M. and Pochapsky, T.C. (2008) A functional proline switch in cytochrome P450_cam. Structure 16, 916-923.

20 June 2008.

• McCoy, J.G., Johnson, H..D, Singh, S., Bingman, C.A., Lei, I.-K., Thorson, J.S. and Phillips, G.N., Jr. (2008) Structural characterization of CalO2: A putative orsellinic acid P450 oxidase in the calicheamicin biosynthetic pathway. Proteins 74, 50-60.

13 June 2008.

• Ma, Q. and Lu, A.Y. (2008) The challenges of dealing with promiscuous drug-metabolizing enzymes, receptors and transporters. Curr. Drug Metab. 9, 374-383.

6 June 2008.

• Pechurskaya, T.A., Lukashevich, O.P., Gilep, A.A. and Usanov, S.A. (2008) Engineering, expression, and purification of "soluble" human cytochrome P45017 and its functional characterization. Biochemistry (Moscow) 73, 806-811.

30 May 2008.

• Zawaira, A., Matimba, A. and Masimirembwa C. (2008) Prediction of sites under adaptive evolution in cytochrome P450 sequences and their relationship to substrate recognition sites. Pharmacogenetics & Genomics 18, 467-476.

23 May 2008.

• Miller, W.L. (2008) Steroidogenic enzymes. Endocr. Dev. 13, 1-18.

16 May 2008.

• Giron, M.C., Portolan, S., Bin, A., Mazzi, U. and Cutler, C.S. (2008) Cytochrome P450 and radiopharmaceutical metabolism. Q. J. Nucl. Med. Mol. Imaging 52, 254-266.

2 May 2008.

• White, M.A., Mast, N., Bjorkhem, I., Johnson, E.F., Stout, C.D. and Pikuleva, I.A. (2008) Use of complementary cation and anion heavy-atom salt derivatives to solve the structure of cytochrome P450 46A1. Acta Crystallogr. D64, 487-495.

25 April 2008.

• Salerno, J.C. (2008) Neuronal nitric oxide synthase: Prototype for pulsed enzymology. FEBS Lett. 582, 1395-1399.

18 April 2008.

Control of aggressiveness by social regulation of cytochrome P450s?

• Wang, L., Dankert, H., Perona, P. and Anderson, D.J. (2008) A common genetic target for environmental and heritable influences on aggressiveness in Drosophila. Proc. Natl. Acad. Sci. USA 105, 5657-5663.

11 April 2008.

• Ewen, K.M., Schiffler, B., Uhlmann-Schiffler, H., Bernhardt, R. and Hannemann, F. (2008) The endogenous adrenodoxin reductase-like flavoprotein arh1 supports heterologous cytochrome P450-dependent substrate conversions in Schizosaccharomyces pombe. FEMS Yeast Res. 8, 432-441.

28 March 2008.

• Adams, J.S., Chen, H., Chun, R., Ren, S., Wu, S., Gacad, M., Nguyen, L., Ride, J., Liu, P., Modlin, R. and Hewison, M. (2007) Substrate and enzyme trafficking as a means of regulating 1,25-dihydroxyvitamin D synthesis and action: the human innate immune response. J. Bone Miner. Res. 22, Suppl. 2, V20-V24.

21 March 2008.

• Aliverti, A., Pandini, V., Pennati, A., de Rosa, M. and Zanetti, G. (2008) Structural and functional diversity of ferredoxin-NADP⁺ reductases. Arch. Biochem. Biophys. 474, 283-291.

14 March 2008.

• Manna, S.K. and Mazumdar, S. (2008) Reversible inactivation of cytochrome P450 by alkaline earth metal ions: Auxiliary metal ion induced conformation change and formation of inactive P420 species in CYP101. J. Inorg. Biochem. 102, 1312-1321.

7 March 2008.

• Sugimoto, H., Shinkyo, R., Hayashi, K., Yoneda, S., Yamada, M., Kamakura, M., Ikushiro, S.I., Shiro, Y. and Sakaki, T. (2008) Crystal structure of CYP105A1 (P450SU-1) in complex with 1α,25-dihydroxyvitamin D₃. Biochemistry 47, 4017-4027.

29 February 2008.

• Maghzal, G.J., Thomas, S.R., Hunt, N.H. and Stocker, R. (2008) Cytochrome b₅, not superoxide anion radical, is a major reductant of indoleamine 2,3-dioxygenase in human cells. J. Biol. Chem. 283, 12014-12025.

22 February 2008.

• Brown, C.M., Reisfeld, B. and Mayeno, A.N. (2008) Cytochromes P450: a structure-based summary of biotransformations using representative substrates. Drug Metab. Rev. 40, 1-100.

8 February 2008.

• Kimura, I., Nakayama, Y., Yamauchi, H., Konishi, M., Miyake, A., Mori, M., Ohta, M., Itoh, N. and Fujimoto, M. (2008) Neurotrophic activity of neudesin, a novel extracellular heme-binding protein, is dependent on the binding of heme to its cytochrome b₅-like heme/steroid-binding domain. J. Biol. Chem. 283, 4323-4331.

1 February 2008.

• Gleeson, M.P. (2008) Generation of a set of simple, interpretable ADMET rules of thumb. J. Med. Chem. 51, 817-834.

25 January 2008.

• Gonzalez-Kristeller, D.C., Farage, L., Fiorini, L.C., Loomis, W.F. and da Silva, A.M. (2008) The P450 oxidoreductase, RedA, controls development beyond the mound stage in Dictyostelium discoideum. BMC Dev. Biol. 8, 8.

18 January 2008.

• Ho, W.W., Li, H., Nishida, C.R., Ortiz de Montellano, P.R. and Poulos, T.L. (2008) Crystal structure and properties of CYP231A2 from the thermoacidophilic archaeon Picrophilus torridus. Biochemistry 47, 2071-2079.

11 January 2008.

• Rontein, D., Onillon, S., Herbette, G., Lesot, A., Werck-Reichhart, D., Sallaud, C. and Tissier, A. (2008) CYP725A4 from yew catalyzes complex structural rearrangment of taxa-4(5)-11(12)-diene into the cyclic ether 5(12)-oxa-3(11)-cyclotaxane. J. Biol. Chem. 283, 6067-6075.

4 January 2008.

• Newcomb, M., Halgrimson, J.A., Horner, J.H., Wasinger, E.C., Chen, L.X. and Sligar, S.G. (2008) X-ray absorption spectroscopic characterization of a cytochrome P450 compound II derivative. Proc. Natl. Acad. Sci. USA 105, 8179-8184.

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