Neighbor-join tree of representative P450 protein sequences. Organisms are abbreviated as shown below. Branches and labels are color-coded according to phylogenetic classification. Mammals: red; other vertebrates: dark brown; insects: brown; other invertebrates light brown; nematodes: orange; plants: green; fungi: dark blue; protist: dark green; prokaryotes: magenta. The P450 superfamily members are divided into two classes (E- and B-classes). The E-class members are further classified into six major groups (I-VI) indicated by Roman numbers. This tree was presented at the Fifth International Symposium on P450 Biodiversity, July 2-6, 2000, Elsinore, Denmark. Afl Aspergillus flavus [FNG] Ame Amycolatopsis mediterranei [BAC] Ani Aspergillus niger [FNG] Ath Arabidopsis thaliana [PLN] thale cress Atu Agrobacterium tumefaciens [BAC] Ava Anabaena variabilis [BAC] Bdi Blaberus discoidalis [INS] cockroach Bja Bradyrhizobium japonicum [BAC] Bme Bacillus megaterium [BAC] Bmi Boophilus microplus [INS] southern cattle tick Bst Berberis stolonifera [PLN] barberry Bsu Bacillus subtilis [BAC] Cci Coprinus cinereus [FNG] mushroom Cel Caenorhabditis elegans [NEM] nematode Cpi Culex pipiens quinquefasciatus [INS] mosquito Cro Catharanthus roseus [PLN] Madagascar periwinkle Cto Cylindrocarpon tonkinense [FNG] Ctr Candida tropicalis [FNG] Ddi Dictyostelium discoideum [PRT] cellular slime mold Dme Drosophila melanogaster [INS] fruit fly Dre Danio rerio [VRT] zebrafish Dsa Dasyatis sabina [VRT] Atlantic stingray Eca Eschscholzia californica [PLN] California poppy Eni Emericella nidulans [FNG] Fhe Fundulus heteroclitus [VRT] killifish Fox Fusarium oxysporum [FNG] Fsp Fusarium sporotrichioides [FNG] Gec Glycyrrhiza echinata [PLN] licorice Gfu Gibberella fujikuroi [FNG] Gga Gallus gallus [VRT] chicken Gma Glycine max [PLN] soybean Ham Homarus americanus [INV] American lobster Hsp Homo sapiens [MAN] human Htu Helianthus tuberosus [PLN] Hvi Heliothis virescens [INS] tobacco budworm Les Lycopersicon esculentum [PLN] tomato Mdo Musca domestica [INS] house fly Mgr Micromonospora griseorubida [BAC] Mme Mercenaria mercenaria [INV] northern quahog (clam) Mse Manduca sexta [INS] tobacco hornworm Msm Mycobacterium smegmatis [BAC] Mtu Mycobacterium tuberculosis [BAC] Ncr Neurospora crassa [FNG] Nha Nectria haematococca [FNG] Noc Nocardioides sp. [BAC] Nta Nicotiana tabacum [PLN] tobacco Ocu Oryctolagus cuniculus [MAN] European rabbit Omy Oncorhynchus mykiss [VRT] rainbow trout Pam Persea americana [PLN] avocado Par Panulirus argus [INV] Florida spiny lobster Phy Petunia x hybrida [PLN] Pin Pseudomonas incognita [BAC] Ppo Papilio polyxenes [INS] butterfly Ppu Pseudomonas putida [BAC] Psa Pisum sativum [PLN] pea Pse Pseudomonas sp. [BAC] Rfa Rhodococcus fascians [BAC] Rhi Rhizobium sp. [BAC] Rho Rhodococcus sp. [BAC] Rmi Rhodotorula minuta [FNG] Sal Sinapis alba [PLN] white mustard San Streptomyces antibioticus [BAC] Sbi Sorghum bicolor [PLN] sorghum Sca Streptomyces carbophilus [BAC] Sce Saccharomyces cerevisiae [FNG] baker's yeast Ser Saccharopolyspora erythraea [BAC] Sfr Streptomyces fradiae [BAC] Sgr Streptomyces griseus [BAC] Shy Streptomyces hygroscopicus [BAC] Sme Solanum melongena [PLN] eggplant Spe Streptomyces peucetius [BAC] Spo Schizosaccharomyces pombe [FNG] fission yeast Sso Sulfolobus Solfataricus [BAC] Sth Streptomyces thermotolerans [BAC] Str Streptomyces sp. [BAC] Syn Synechocystis sp. [BAC] Tca Tribolium castaneum [INS] red flour beetle Tma Triglochin maritima [PLN] Ufa Uromyces fabae [FNG] Vsa Vicia sativa [PLN] spring vetch Xle Xenopus laevis [VRT] African nail frog Zma Zea mays [PLN] maize